Actively Recruiting

Phase 2
Age: 18Years - 80Years
All Genders
NCT07176390

A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)

Led by Merck Sharp & Dohme LLC · Updated on 2026-04-24

182

Participants Needed

62

Research Sites

203 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are looking for new ways to treat rheumatoid arthritis (RA). Methotrexate (MTX) is a standard (usual) treatment for RA. However, MTX and other current treatments may not work well to treat RA symptoms for many people. This study will help find out if a study medicine called tulisokibart can treat symptoms of active RA in people who are taking MTX. In this study, researchers will look at different doses of tulisokibart. Researchers want to learn if at least one of the study doses of tulisokibart works better than a placebo to lessen RA symptoms. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of the study medicine.

CONDITIONS

Official Title

A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Clinical diagnosis of rheumatoid arthritis (RA) meeting 2010 ACR/EULAR classification criteria
  • Active RA with at least 6 tender joints and 6 swollen joints
  • Current treatment with oral or injectable methotrexate (MTX)
  • History of being either biologic disease-modifying antirheumatic drug (bDMARD) naive or having inadequate response or intolerance to up to 2 bDMARD classes
Not Eligible

You will not qualify if you...

  • Arthritis starting before age 17 or diagnosis of other inflammatory joint diseases or conditions interfering with RA assessment
  • History of cancer (except certain skin cancers or cervical carcinoma in situ) unless disease free for 5 years before enrollment
  • Presence of active infection
  • Known allergies or intolerance to tulisokibart or its ingredients

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 62 locations

1

Arizona Arthritis & Rheumatology Associates, P.C. ( Site 1018)

Glendale, Arizona, United States, 85306-9802

Actively Recruiting

2

AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa ( Site 1033)

Mesa, Arizona, United States, 85210

Actively Recruiting

3

Arthritis & Osteoporosis Medical Center - La Palma ( Site 1024)

La Palma, California, United States, 90623

Actively Recruiting

4

Tekton Research, LLC. ( Site 1008)

Fort Collins, Colorado, United States, 80528

Actively Recruiting

5

Sweet Hope Research Specialty, Inc ( Site 1015)

Hialeah, Florida, United States, 33016

Actively Recruiting

6

HMD Research LLC ( Site 1016)

Orlando, Florida, United States, 32819

Actively Recruiting

7

Greater Chicago Specialty Physicians - Orland Park ( Site 1043)

Orland Park, Illinois, United States, 60467

Actively Recruiting

8

AA Medical Research Center ( Site 1027)

Grand Blanc, Michigan, United States, 48439

Actively Recruiting

9

Kansas City Physician Partners ( Site 1032)

Kansas City, Missouri, United States, 64111

Actively Recruiting

10

Physician Research Collaboration, LLC ( Site 1002)

Lincoln, Nebraska, United States, 68516

Actively Recruiting

11

altoona center for clinical research ( Site 1005)

Duncansville, Pennsylvania, United States, 16635

Actively Recruiting

12

Rheumatology Specialty Center ( Site 1030)

Willow Grove, Pennsylvania, United States, 19090

Actively Recruiting

13

AARA Clinical Research - Murfreesboro Medical Clinic ( Site 1034)

Murfreesboro, Tennessee, United States, 37128

Actively Recruiting

14

Rheumatology Associates ( Site 1026)

Arlington, Texas, United States, 76012

Actively Recruiting

15

Epic Medical Research ( Site 1004)

Red Oak, Texas, United States, 75154

Actively Recruiting

16

Advanced Rheumatology of Houston - Woodlands ( Site 1000)

The Woodlands, Texas, United States, 77382

Actively Recruiting

17

Mount Sinai Hospital ( Site 1102)

Toronto, Ontario, Canada, M5T 3L9

Actively Recruiting

18

CIUSSS de l'Estrie - CHUS, Hotel-Dieu de Sherbrooke ( Site 1106)

Sherbrooke, Quebec, Canada, J1G 2E8

Actively Recruiting

19

Centre de Recherche Musculo-Squelettique ( Site 1101)

Trois-Rivières, Quebec, Canada, G9A 3X2

Actively Recruiting

20

Centro de Estudios GyC ( Site 1206)

Santiago, Region M. de Santiago, Chile, 7500504

Actively Recruiting

21

Clinica Dermacross ( Site 1203)

Santiago, Region M. de Santiago, Chile, 7640881

Actively Recruiting

22

CECIM ( Site 1208)

Santiago, Region M. de Santiago, Chile, 8320000

Actively Recruiting

23

Pontificia Universidad Catolica de Chile-CICUC ( Site 1209)

Santiago, Region M. de Santiago, Chile, 8330073

Actively Recruiting

24

Peking University First Hospital ( Site 2511)

Beijing, Beijing Municipality, China, 100034

Actively Recruiting

25

The First Affiliated Hospital of Xiamen University. ( Site 2510)

Xiamen, Fujian, China, 361003

Actively Recruiting

26

The Third Affiliated Hospital, Sun Yat-sen University ( Site 2514)

Guangzhou, Guangdong, China, 510630

Actively Recruiting

27

Xinxiang Central Hospital ( Site 2501)

Xinxiang, Henan, China, 453000

Actively Recruiting

28

Pingxiang People's Hospital ( Site 2512)

Pingxiang, Jiangxi, China, 337000

Actively Recruiting

29

Linfen Central Hospital ( Site 2507)

Linfen, Shanxi, China, 041000

Actively Recruiting

30

PEOPLE'S HOSPITAL OF XINJIANG UYGUR AUTONOMOUS REGION ( Site 2515)

Ürümqi, Xinjiang, China, 830001

Actively Recruiting

31

Taizhou Hospital of Zhejiang Province ( Site 2506)

Linhai, Zhejiang, China, 317000

Actively Recruiting

32

Clinica de la Costa S.A.S. ( Site 1301)

Barranquilla, Atlántico, Colombia, 080020

Actively Recruiting

33

CIREEM SAS ( Site 1304)

Bogota, Cundinamarca, Colombia, 110111

Actively Recruiting

34

Fundación Valle del Lili ( Site 1305)

Cali, Valle del Cauca Department, Colombia, 760032

Actively Recruiting

35

Medicover München Ost MVZ ( Site 1607)

München, Bavaria, Germany, 81667

Actively Recruiting

36

Rheuma-Research Lausitz ( Site 1604)

Cottbus, Brandenburg, Germany, 03042

Actively Recruiting

37

Rheumazentrum Ratingen Studienambulanz ( Site 1601)

Ratingen, North Rhine-Westphalia, Germany, 40878

Actively Recruiting

38

Rheumatologische Schwerpunktpraxis ( Site 1603)

Berlin, Germany, 12161

Actively Recruiting

39

HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg G ( Site 1602)

Hamburg, Germany, 20095

Actively Recruiting

40

Toshin Yoshida Internal Medicine Rheumatology ( Site 2606)

Hanishina-gun, Nagano, Japan, 389-0606

Actively Recruiting

41

Sasebo Chuo Hospital ( Site 2602)

Sasebo, Nagasaki, Japan, 857-1195

Actively Recruiting

42

Nagaoka Red Cross Hospital ( Site 2604)

Nagaoka, Niigata, Japan, 940-2085

Actively Recruiting

43

Hirose Clinic ( Site 2601)

Tokorozawa, Saitama, Japan, 359-1111

Actively Recruiting

44

University of Yamanashi Hospital ( Site 2603)

Chūō, Yamanashi, Japan, 409-3898

Actively Recruiting

45

Kai Clinic ( Site 2600)

Miyazaki, Japan, 880-0053

Actively Recruiting

46

MICS Centrum Medyczne Bydgoszcz ( Site 1807)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-065

Actively Recruiting

47

Szpital Uniwersytecki nr 2 im. Dr. Jana Biziela-Klnk Reumatologii i Ukladowych Chorob Tkanki Lacznej ( Site 1804)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-168

Actively Recruiting

48

MICS Centrum Medyczne Torun ( Site 1803)

Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100

Actively Recruiting

49

Zespół Poradni Specjalistycznych Reumed Filia nr 1 Wallenroda ( Site 1801)

Lublin, Lublin Voivodeship, Poland, 20-607

Actively Recruiting

50

MICS Centrum Medyczne Warszawa ( Site 1805)

Warsaw, Masovian Voivodeship, Poland, 00-874

Actively Recruiting

51

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji ( Site 1806)

Warsaw, Masovian Voivodeship, Poland, 02-637

Actively Recruiting

52

NZOZ BIF-MED ( Site 1802)

Bytom, Silesian Voivodeship, Poland, 41-902

Actively Recruiting

53

Soon Chun Hyang University Cheonan Hospital ( Site 2304)

Cheonan-si, Chungcheongnam-do, South Korea, 31151

Actively Recruiting

54

Chungnam national university hospital ( Site 2303)

Daejeon, Taejon-Kwangyokshi, South Korea, 35015

Actively Recruiting

55

Hanyang University Seoul Hospital ( Site 2300)

Seoul, South Korea, 04763

Actively Recruiting

56

Hospital Universitari Parc Tauli ( Site 1900)

Sabadell, Barcelona, Spain, 8208

Actively Recruiting

57

Hospital Universitario Marqués de Valdecilla ( Site 1906)

Santander, Cantabria, Spain, 39008

Actively Recruiting

58

Hospital Clinico Universitario de Santiago ( Site 1903)

Santiago de Compostela, La Coruna, Spain, 15706

Actively Recruiting

59

Hospital Universitari Vall d'Hebron ( Site 1901)

Barcelona, Spain, 08035

Actively Recruiting

60

The Princess Alexandra Hospital NHS Trust ( Site 2103)

Harlow, England, United Kingdom, CM20 1QX

Actively Recruiting

61

Chapel Allerton Hospital ( Site 2106)

Leeds, United Kingdom, LS7 4SA

Actively Recruiting

62

Barnet Hospital ( Site 2102)

London, United Kingdom, EN5 3DJ

Actively Recruiting

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Research Team

T

Toll Free Number

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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