Actively Recruiting
A Clinical Study of Ultra-transplantation for the Treatment of Major Thalassemia Scheme
Led by Hu Peng · Updated on 2025-09-02
5
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Yunnan is a high-incidence area of Eastern Mediterranean (thalassemia) in China, and the treatment cost of thalassemia patients is high, hematopoietic stem cell transplantation (HSCT) is the only means to cure thalassemia, but there are problems in donor screening and the risk of complications. Professor Ai Huisheng's team proposed a new concept of hypertransplantation, which does not require pretreatment and has no risk of GVHD, and animal experiments have shown good efficacy. Under the guidance of Professor Ai, the center plans to carry out clinical research on hypertransplantation and explore safe and effective new therapies for thalassemia.
CONDITIONS
Official Title
A Clinical Study of Ultra-transplantation for the Treatment of Major Thalassemia Scheme
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with severe Mediterranean anemia, including alpha and beta types
- Age between 7 and 12 years, any gender, weight less than 40 kg
- Patient has or does not have HLA matched or semi-matched donors but refuses or is not eligible for blood stem cell transplantation
- Patient refuses or is not eligible for gene therapy for thalassemia
- Suitable HLA matched or mismatched donors who meet donor criteria are available
- Patient and family agree to receive hypertransplantation treatment and have signed informed consent
You will not qualify if you...
- Psychiatric patients
- Participation in other drug clinical trials within the past month
- No suitable HLA mismatched donors available
- Determined unsuitable for study participation by researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yunnan First People's Hospital
Kunming, Yunnan, China, 650000
Actively Recruiting
Research Team
Y
Yang tonghua T Yang, master
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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