Actively Recruiting
Clinical Study on Using TCR to Predict the Effect of Tislelizumab + Chemotherapy in the First-line Treatment of ES-SCLC
Led by Henan Cancer Hospital · Updated on 2025-11-24
40
Participants Needed
1
Research Sites
123 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective observational clinical study designed to predict the therapeutic efficacy of first-line treatment with tislelizumab combined with standard chemotherapy in patients with ES-SCLC using TCR repertoire technology. The study plans to enroll 40 treatment-naive patients with ES-SCLC.
CONDITIONS
Official Title
Clinical Study on Using TCR to Predict the Effect of Tislelizumab + Chemotherapy in the First-line Treatment of ES-SCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed extensive-stage small cell lung cancer (Stage IV or T3-4 not eligible for tolerable radiotherapy)
- Asymptomatic or stable brain metastases with steroid and anticonvulsant treatment for at least 1 month before study treatment
- At least one measurable tumor lesion according to RECIST v1.1
- Age 18 years or older
- Eastern Cooperative Oncology Group (ECOG) physical status score of 0-1
You will not qualify if you...
- History of chest radiotherapy or planned intensive chest radiotherapy before systemic treatment
- Previous or current non-infectious pneumonia requiring systemic glucocorticoid therapy or combined with mild to moderate interstitial pneumonia
- Unresolved toxicity from prior cancer treatments not recovered to required levels
- History of allogeneic organ or hematopoietic stem cell transplantation requiring immunosuppression
- Chronic hepatitis B with HBV DNA ≥500 IU/mL or hepatitis C
- Other conditions as determined by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Henan Cancer Hosipital
Zhengzhou, Henan, China, 450000
Actively Recruiting
Research Team
H
Henan Province Cancer Hospital Ethics Committee Henan Province Cancer Hospital Ethics Committee
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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