Actively Recruiting
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-08
594
Participants Needed
123
Research Sites
400 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing. The goal of this study is to learn if more people who receive zilovertamab vedotin (MK-2140) and R-CHP have the cancer respond (go away) than those who receive polatuzumab vedotin and R-CHP.
CONDITIONS
Official Title
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Who Can Participate
Eligibility Criteria
You may qualify if you...
The main inclusion criteria include but are not limited to the following:
- Has histologically confirmed diagnosis of germinal center B-cell (GCB) subtype of diffuse large B-cell lymphoma (DLBCL), by prior biopsy, according to the World Health Organization (WHO) classification of neoplasms of the hematopoietic and lymphoid tissues.
- Has positron emission tomography (PET) positive disease at screening, defined as 4 to 5 on the Lugano 5-point scale.
- Has received no prior treatment for their DLBCL.
- Human immunodeficiency virus (HIV) infected participants must have well controlled HIV on antiretroviral therapy (ART).
- Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load prior to randomization.
- Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening.
You will not qualify if you...
The main exclusion criteria include but are not limited to the following:
- Has a history of transformation of indolent disease to DLBCL.
- Has received a diagnosis of primary mediastinal B-cell lymphoma (PMBCL) or Grey zone lymphoma.
- Has Ann Arbor Stage I DLBCL.
- Has clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<6 months prior to enrollment), myocardial infarction (<6 months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class ≥II), or serious cardiac arrhythmia requiring medication.
- Has clinically significant pericardial or pleural effusion.
- Has ongoing Grade >1 peripheral neuropathy.
- Has a demyelinating form of Charcot-Marie-Tooth disease.
- HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease.
- Has ongoing corticosteroid therapy.
- Known additional malignancy that is progressing or has required active treatment within the past 2 years.
- Known active central nervous system (CNS) lymphoma.
- Has active autoimmune disease that has required systemic treatment in the past 2 years.
- Has active infection requiring systemic therapy.
- Has active HBV (defined as HBsAg positive and detectable HBV deoxyribonucleic acid (DNA)) and HCV (defined as anti-HCV antibody positive and detectable HCV ribonucleic acid (RNA)) infection.
- Has history of stem cell/solid organ transplant.
AI-Screening
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Trial Site Locations
Total: 123 locations
1
Infirmary Cancer Care ( Site 0157)
Mobile, Alabama, United States, 36607
Actively Recruiting
2
Ironwood Cancer & Research Centers ( Site 0204)
Chandler, Arizona, United States, 85224
Actively Recruiting
3
Palo Verde Cancer Specialists ( Site 0105)
Glendale, Arizona, United States, 85304
Actively Recruiting
4
Genesis Cancer and Blood Institute ( Site 0193)
Hot Springs, Arkansas, United States, 71913
Actively Recruiting
5
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0135)
Burbank, California, United States, 91505
Actively Recruiting
6
City of Hope Comprehensive Cancer Center ( Site 0191)
Duarte, California, United States, 91010
Actively Recruiting
7
Bass Medical Group ( Site 0123)
Walnut Creek, California, United States, 94598
Actively Recruiting
8
Rocky Mountain Cancer Centers (RMCC) ( Site 8001)
Aurora, Colorado, United States, 80012
Actively Recruiting
9
Colorado West Healthcare System-Grand Valley Oncology ( Site 0165)
Grand Junction, Colorado, United States, 81505
Actively Recruiting
10
Medical Oncology Hematology Consultants (MOHC) ( Site 8007)
Newark, Delaware, United States, 19713
Actively Recruiting
11
Georgetown University Medical Center ( Site 0117)
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
12
Boca Raton Regional Hospital-Lynn Cancer Institute ( Site 0130)
Boca Raton, Florida, United States, 33486
Actively Recruiting
13
Baptist MD Anderson Cancer Center ( Site 0176)
Jacksonville, Florida, United States, 32207
Actively Recruiting
14
Mount Sinai Cancer Center ( Site 0140)
Miami Beach, Florida, United States, 33140
Actively Recruiting
15
Mid Florida Hematology and Oncology Center ( Site 0152)
Orange City, Florida, United States, 32763
Actively Recruiting
16
Beacon Cancer Care ( Site 0142)
Post Falls, Idaho, United States, 83854
Actively Recruiting
17
University of Chicago Medical Center ( Site 0126)
Chicago, Illinois, United States, 60637
Actively Recruiting
18
Illinois Cancer Care ( Site 7005)
Peoria, Illinois, United States, 61615
Actively Recruiting
19
University of Iowa-Holden Comprehensive Cancer Center ( Site 0139)
Iowa City, Iowa, United States, 52242
Actively Recruiting
20
Mission Blood & Cancer Care ( Site 0114)
Waukee, Iowa, United States, 50263
Actively Recruiting
21
Saint Elizabeth Medical Center Edgewood ( Site 0141)
Edgewood, Kentucky, United States, 41017
Actively Recruiting
22
Baptist Health Hardin ( Site 0154)
Elizabethtown, Kentucky, United States, 42701
Actively Recruiting
23
Baptist Health Lexington ( Site 0127)
Lexington, Kentucky, United States, 40503
Actively Recruiting
24
Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185)
Louisville, Kentucky, United States, 40207
Actively Recruiting
25
Our Lady of the Lake Physician Group-Medical Oncology ( Site 0180)
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
26
Ochsner LSU Health - Monroe Medical Center, Family Medicine Clinic ( Site 0209)
Monroe, Louisiana, United States, 71202
Actively Recruiting
27
Ochsner Clinic Foundation ( Site 0189)
New Orleans, Louisiana, United States, 70121
Actively Recruiting
28
Louisiana State University Health Sciences Shreveport ( Site 0195)
Shreveport, Louisiana, United States, 71103
Actively Recruiting
29
Dana Farber Cancer Institute ( Site 0111)
Boston, Massachusetts, United States, 02215
Actively Recruiting
30
Minnesota Oncology Hematology (MNO) ( Site 8004)
Burnsville, Minnesota, United States, 55337
Actively Recruiting
31
Bozeman Health Deaconess Hospital ( Site 0183)
Bozeman, Montana, United States, 59715
Actively Recruiting
32
NHO Revive Research Institute, LLC ( Site 0121)
Lincoln, Nebraska, United States, 68506
Actively Recruiting
33
University Of Nebraska Medical Center ( Site 0110)
Omaha, Nebraska, United States, 68198
Actively Recruiting
34
Atlantic Health Morristown Medical Center ( Site 0163)
Morristown, New Jersey, United States, 07960
Actively Recruiting
35
Valley Health Systems - Ridgewood Campus ( Site 0125)
Paramus, New Jersey, United States, 07652
Actively Recruiting
36
Erie County Medical Center ( Site 0175)
Buffalo, New York, United States, 14215
Actively Recruiting
37
Roswell Park Cancer Institute ( Site 0192)
Buffalo, New York, United States, 14263
Actively Recruiting
38
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0208)
Mineola, New York, United States, 11501
Actively Recruiting
39
Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0108)
New York, New York, United States, 10016
Actively Recruiting
40
SUNY Upstate Cancer Center ( Site 0178)
Syracuse, New York, United States, 13210
Actively Recruiting
41
Clinical Research Alliance ( Site 0122)
Westbury, New York, United States, 11590
Actively Recruiting
42
University of North Carolina Medical Center ( Site 0136)
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
43
Novant Health Presbyterian Medical Center ( Site 0177)
Charlotte, North Carolina, United States, 28204
Actively Recruiting
44
Novant Health Forsyth Medical Center ( Site 0206)
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
45
University of Cincinnati Medical Center ( Site 0156)
Cincinnati, Ohio, United States, 45219
Actively Recruiting
46
University Hospitals of Cleveland ( Site 0155)
Cleveland, Ohio, United States, 44106
Actively Recruiting
47
Fairview Hospital-Moll Cancer Center ( Site 0198)
Cleveland, Ohio, United States, 44111
Actively Recruiting
48
Cleveland Clinic Main ( Site 0101)
Cleveland, Ohio, United States, 44195
Actively Recruiting
49
Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 0199)
Mayfield Heights, Ohio, United States, 44124
Actively Recruiting
50
Providence Portland Medical Center ( Site 0120)
Portland, Oregon, United States, 97213
Actively Recruiting
51
Providence Oncology and Hematology Clinic Westside ( Site 0179)
Portland, Oregon, United States, 97225
Actively Recruiting
52
Temple University Hospital ( Site 0133)
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
53
Alliance Cancer Specialists (ACS) ( Site 8010)
Sellersville, Pennsylvania, United States, 18960
Actively Recruiting
54
Cancer Care Associates Of York ( Site 0174)
York, Pennsylvania, United States, 17403
Actively Recruiting
55
Medical University of South Carolina ( Site 0153)
Charleston, South Carolina, United States, 29425
Actively Recruiting
56
Tennessee Cancer Specialists ( Site 7004)
Knoxville, Tennessee, United States, 37909
Actively Recruiting
57
SCRI Oncology Partners ( Site 7002)
Nashville, Tennessee, United States, 37203
Actively Recruiting
58
Texas Oncology - West Texas ( Site 8008)
Amarillo, Texas, United States, 79124
Actively Recruiting
59
Texas Oncology - Central/South Texas ( Site 8006)
Austin, Texas, United States, 78705
Actively Recruiting
60
Texas Oncology - Northeast Texas ( Site 8002)
Palestine, Texas, United States, 75801
Actively Recruiting
61
Texas Oncology - San Antonio ( Site 8009)
San Antonio, Texas, United States, 78240
Actively Recruiting
62
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0145)
Tyler, Texas, United States, 75701
Completed
63
Intermountain Medical Center ( Site 0182)
Murray, Utah, United States, 84107
Actively Recruiting
64
Intermountain Healthcare - St. George ( Site 0203)
St. George, Utah, United States, 84790
Actively Recruiting
65
Virginia Cancer Specialists, PC ( Site 8003)
Manassas, Virginia, United States, 20110
Actively Recruiting
66
VCU Health Adult Outpatient Pavillion ( Site 0138)
Richmond, Virginia, United States, 23219
Actively Recruiting
67
Northwest Cancer Specialists (Compass Oncology) ( Site 8000)
Vancouver, Washington, United States, 98684
Actively Recruiting
68
SSM Health Dean Medical Group ( Site 0106)
Madison, Wisconsin, United States, 53715
Actively Recruiting
69
Medical College of Wisconsin ( Site 0103)
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
70
AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0306)
Mechelen, Antwerpen, Belgium, 2800
Actively Recruiting
71
Cliniques Universitaires Saint-Luc ( Site 0302)
Brussels, Bruxelles-Capitale, Region de, Belgium, 1200
Actively Recruiting
72
Hopital de Jolimont ( Site 0304)
Haine-Saint-Paul, Hainaut, Belgium, 7100
Actively Recruiting
73
UZ Leuven ( Site 0301)
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
74
AZ Delta ( Site 0303)
Roeselare, West-Vlaanderen, Belgium, 8800
Actively Recruiting
75
Uniklinik Erlangen ( Site 0412)
Erlangen, Bavaria, Germany, 91054
Actively Recruiting
76
Universitaetsklinikum Wuerzburg ( Site 0401)
Würzburg, Bavaria, Germany, 97080
Actively Recruiting
77
HELIOS Klinikum Wuppertal ( Site 0435)
Wuppertal, North Rhine-Westphalia, Germany, 42283
Actively Recruiting
78
Otto-Von-Guericke-Universitaet Magdeburg ( Site 0411)
Magdeburg, Saxony-Anhalt, Germany, 39120
Actively Recruiting
79
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck ( Site 0425)
Lübeck, Schleswig-Holstein, Germany, 23562
Actively Recruiting
80
St Vincent's University Hospital ( Site 0502)
Dublin, Dublin, Ireland, D04 T6F4
Actively Recruiting
81
Mater Misercordiae University Hospital ( Site 0501)
Dublin, Ireland, D07 R2WY
Actively Recruiting
82
University Hospital Limerick ( Site 0503)
Limerick, Ireland, V94 F858
Actively Recruiting
83
Soroka Medical Center ( Site 0606)
Beersheba, Israel, 8410101
Actively Recruiting
84
Rambam Health Care Campus ( Site 0604)
Haifa, Israel, 3109601
Actively Recruiting
85
Edith Wolfson Medical Center ( Site 0602)
Holon, Israel, 5810001
Actively Recruiting
86
Haddasah Medical Center ( Site 0601)
Jerusalem, Israel, 9112001
Actively Recruiting
87
Rabin Medical Center ( Site 0607)
Petah Tikva, Israel, 4941492
Actively Recruiting
88
Sheba Medical Center ( Site 0603)
Ramat Gan, Israel, 5265601
Actively Recruiting
89
ZIV Medical Center ( Site 0605)
Safed, Israel, 13100
Actively Recruiting
90
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 0707)
Meldola, Forli-Cesena, Italy, 47014
Actively Recruiting
91
Istituto Clinico Humanitas ( Site 0704)
Rozzano, Milano, Italy, 20089
Actively Recruiting
92
Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0703)
Alessandria, Italy, 15121
Actively Recruiting
93
Istituto Europeo di Oncologia ( Site 0701)
Milan, Italy, 20141
Actively Recruiting
94
Universita degli Studi di Napoli Federico II ( Site 0705)
Naples, Italy, 80131
Actively Recruiting
95
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 0702)
Palermo, Italy, 90146
Actively Recruiting
96
Arcispedale Santa Maria Nuova ( Site 0706)
Reggio Emilia, Italy, 42123
Actively Recruiting
97
Aichi Cancer Center ( Site 1007)
Nagoya, Aichi-ken, Japan, 464-8681
Actively Recruiting
98
Fujita Health University Hospital ( Site 1003)
Toyoake, Aichi-ken, Japan, 470-1192
Actively Recruiting
99
Hokkaido University Hospital ( Site 1004)
Sapporo, Hokkaido, Japan, 060-8648
Actively Recruiting
100
National Hospital Organization Sendai Medical Center ( Site 1005)
Sendai, Miyagi, Japan, 983-8520
Actively Recruiting
101
Kansai Medical University Hospital ( Site 1006)
Hirakata, Osaka, Japan, 573-1191
Actively Recruiting
102
Shimane University Hospital ( Site 1002)
Izumo, Shimane, Japan, 693-8501
Actively Recruiting
103
Nippon Medical School Hospital ( Site 1001)
Bunkyo, Tokyo, Japan, 113-8603
Actively Recruiting
104
National Cancer Center Hospital ( Site 1009)
Chūō, Tokyo, Japan, 104-0045
Actively Recruiting
105
Nagasaki University Hospital ( Site 1008)
Nagasaki, Japan, 852-8501
Actively Recruiting
106
Pratia MCM Krakow ( Site 0804)
Karkow, Lesser Poland Voivodeship, Poland, 30-727
Actively Recruiting
107
Szpital Specjalistyczny im. Jedrzeja Sniadeckiego w Nowym Saczu ( Site 0806)
Nowy Sącz, Lesser Poland Voivodeship, Poland, 33-300
Actively Recruiting
108
Specjalistyczny Szpital im. Dr Alfreda Sokolowskiego w Walbrzychu ( Site 0807)
Wałbrzych, Lower Silesian Voivodeship, Poland, 58-309
Actively Recruiting
109
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0803)
Warsaw, Masovian Voivodeship, Poland, 02-781
Actively Recruiting
110
Uniwersyteckie Centrum Kliniczne ( Site 0802)
Gdansk, Pomeranian Voivodeship, Poland, 80-214
Actively Recruiting
111
Pratia Onkologia Katowice ( Site 0801)
Katowice, Silesian Voivodeship, Poland, 40-519
Actively Recruiting
112
Bristol Haematology and Oncology Centre ( Site 0908)
Bristol, Bristol, City of, United Kingdom, BS2 8ED
Actively Recruiting
113
Stoke Mandeville Hospital ( Site 0917)
Aylesbury, Buckinghamshire, United Kingdom, HP21 8AL
Actively Recruiting
114
Royal Devon & Exeter Hospital ( Site 0910)
Exeter, Devon, United Kingdom, EX2 5DW
Actively Recruiting
115
University Hospitals Plymouth NHS Trust ( Site 0905)
Plymouth, Devon, United Kingdom, PL68DH
Actively Recruiting
116
The James Cook University Hospital ( Site 0909)
Middlesbrough, England, United Kingdom, TS4 3BW
Actively Recruiting
117
Lincoln County Hospital ( Site 0906)
Lincoln, Lincolnshire, United Kingdom, LN2 5QY
Actively Recruiting
118
Guy s & St Thomas NHS Foundation Trust ( Site 0904)
London, London, City of, United Kingdom, SE1 9RT
Actively Recruiting
119
Hammersmith Hospital ( Site 0915)
London, London, City of, United Kingdom, W12 0 HS
Actively Recruiting
120
Churchill Hospital ( Site 0903)
Oxford, Oxfordshire, United Kingdom, OX3 7LJ
Actively Recruiting
121
Queen Elizabeth Hospital Birmingham ( Site 0912)
Birmingham, United Kingdom, B15 2TH
Actively Recruiting
122
Clatterbridge Cancer Centre - Liverpool ( Site 0911)
Liverpool, United Kingdom, L7 8YA
Actively Recruiting
123
Christie Hospital NHS Trust ( Site 0901)
Manchester, United Kingdom, M20 4BX
Actively Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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