Actively Recruiting
Clinical Transcriptomics in Systemic Vasculitis (CUTIS)
Led by Peter Merkel · Updated on 2026-01-22
50
Participants Needed
10
Research Sites
621 weeks
Total Duration
On this page
Sponsors
P
Peter Merkel
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.
CONDITIONS
Official Title
Clinical Transcriptomics in Systemic Vasculitis (CUTIS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis
- Have a suspected or confirmed diagnosis of Cryoglobulinemic vasculitis (CV), Drug-induced vasculitis, Eosinophilic granulomatosis with polyangiitis (EGPA), IgA vasculitis, Isolated cutaneous vasculitis, Granulomatosis with polyangiitis (GPA), Microscopic polyangiitis (MPA), Polyarteritis nodosa (PAN), or Urticarial vasculitis
- Be willing and able to provide written informed consent (or assent for those under 18 years)
You will not qualify if you...
- Are younger than 5 years old
- Not a candidate for biopsy or have a higher risk of infection, bleeding, or other complications from biopsy as determined by a doctor
- Have a neutrophil count less than 1500/mm3, platelet count less than 50,000/mm3, or hemoglobin less than 7 g/dL
- Have an uncontrolled disease that would prevent completion of study procedures
- Have an active infection near the biopsy site, poor circulation, or bony prominence increasing complication risk
- Are pregnant or nursing
- Are unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
University of California, Los Angeles
Los Angeles, California, United States, 90095
Completed
2
Boston University School of Medicine
Boston, Massachusetts, United States, 02118
Completed
3
Mayo Clinic
Rochester, Minnesota, United States, 55905
Completed
4
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Completed
5
Oregon Health & Science University
Portland, Oregon, United States
Completed
6
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
7
University of Utah
Salt Lake City, Utah, United States
Completed
8
University of Virginia
Charlottesville, Virginia, United States, 22903
Actively Recruiting
9
St. Joseph's Healthcare
Hamilton, Ontario, Canada
Actively Recruiting
10
University of Toronto Mount Sinai Hospital
Toronto, Ontario, Canada, M5G 1X5
Actively Recruiting
Research Team
C
Carol McAlear, MA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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