Actively Recruiting
Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC)
Led by Eye & ENT Hospital of Fudan University · Updated on 2025-12-04
1000
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
E
Eye & ENT Hospital of Fudan University
Lead Sponsor
C
Changhai Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
For early stage laryngeal carcinoma and hypohparyngeal carcinoma (T1 and T2), transoral laser microsurgery, open partial laryngectomy, radiotherapy, and transoral robotic surgery were performed according to NCCN guidelines (2020). For advanced stage laryngeal carcinoma and hypohparyngeal carcinoma (T3 and T4), surgical treatment ± postoperative adjuvant therapy, chemoradiotherapy, neoadjuvant therapy + radiotherapy/chemoradiotherapy, or neoadjuvant therapy + surgery + radiotherapy or chemoradiotherapy performed according to NCCN guidelines (2020). This study plan to analyze the clinical ouctomes of different treatment for the same T stage disease. The overall survival rate, disease specific survival, disease free survival, local control, regional control, and laryngeal function preservation rate were analyzed in this study.
CONDITIONS
Official Title
Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of laryngeal cancer (glottic, supraglottic, subglottic) or hypopharyngeal cancer (pyriform sinus, postcricoid, posterior pharyngeal wall)
- Cancer stages T1, T2, T3, or T4
- Age between 18 and 90 years
- Male or female
- Good compliance with study requirements
- No severe related diseases affecting treatment such as other tumors or severe heart, lung, or central nervous system diseases
- Negative pregnancy test for females of childbearing potential
- Agreement to use contraception during the study and for at least 6 months after last cisplatin dose for males and females with fertility
- Female patients who are not fertile or are postmenopausal
You will not qualify if you...
- Previous diagnosis of immunodeficiency, HIV, or AIDS-related diseases
- Known history of active tuberculosis
- Pregnant or breastfeeding women
- Medical conditions deemed inappropriate for study participation by doctors, including severe acute or chronic illnesses such as immune colitis, inflammatory bowel disease, non-infectious pneumonia, pulmonary fibrosis, or recent/active mental illness including suicidal ideation or behavior
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lei Tao
Shanghai, Shanghai Municipality, China, 200031
Actively Recruiting
Research Team
L
Lei Tao, Dr.
CONTACT
H
Hongli Gong, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
8
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