Actively Recruiting
Clinical Trial on Antibiotic-Lock in Tenckhoff Catheter for Relasping and Repeat Peritonitis
Led by Alice Ho Miu Ling Nethersole Hospital · Updated on 2024-01-31
46
Participants Needed
1
Research Sites
172 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Biofilm formation is an important cause of catheter-related infection. In hemodialysis, use of an antibiotic-lock has been proven to be effective to manage such a complication with preservation of the central venous catheter. In peritoneal dialysis, while biofilm has been implicated in relapsing and repeat peritonitis, both of which are caused by the identical bacteria as in their preceding peritonitis episode, no adjunctive measure has been proven to be effective to eradicate the biofilm bacteria. As a result, Tenckhoff catheter removal is the only recommended option for the patients suffering from relapsing or repeat peritonitis. In this study, the investigators are going to investigate whether the use of an antibiotic-lock can be useful to eradicate the biofilm in the Tenckhoff catheter to prevent future episodes of peritonitis caused by the same organism.
CONDITIONS
Official Title
Clinical Trial on Antibiotic-Lock in Tenckhoff Catheter for Relasping and Repeat Peritonitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Peritoneal dialysis patients with relapsing peritonitis within 4 weeks of completing antibiotics or repeat peritonitis between 4 to 12 weeks after antibiotics, with the same causative organism
- Persistent bacterial growth from PD effluent after 2-week antibiotic treatment despite symptom resolution and low PDE leukocyte count
- Age over 18 years
- Informed consent provided
You will not qualify if you...
- No response to appropriate intraperitoneal antibiotics requiring catheter removal
- Fungal or mycobacterial peritonitis
- Co-existing exit site or tunnel tract infection
- Tenckhoff catheter drainage dysfunction
- Age 3 years or younger
- Pregnant patients
AI-Screening
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Trial Site Locations
Total: 1 location
1
Alice Ho Miu Ling Nethersole Hospital
Tai Po, Hong Kong
Actively Recruiting
Research Team
P
Ping Kwan Chan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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