Actively Recruiting
Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in Patients With Vascular Ehlers-Danlos Syndrome
Led by Acer Therapeutics Inc. · Updated on 2025-08-24
150
Participants Needed
1
Research Sites
333 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, Phase 3, randomized, double-blind, placebo-controlled efficacy study to evaluate celiprolol in patients genetically confirmed as COL3A1-positive vEDS using a decentralized clinical trial design.
CONDITIONS
Official Title
Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in Patients With Vascular Ehlers-Danlos Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willingness to obtain magnetic resonance angiogram (MRA) image at a local imaging facility
- Genetic test confirming presence of a pathogenic COL3A1 variant classified as likely pathogenic or pathogenic
- Age 15 years or older at the time of randomization
- Able and willing to discontinue use of beta-blockers before randomization
You will not qualify if you...
- No confirmed COL3A1 pathogenic variant or presence of a COL3A1 haploinsufficiency variant
- Arterial rupture, dissection, uterine rupture, or intestinal rupture within 6 months before screening
- Unable to stop beta-blocker treatment before randomization
- Unable or unwilling to complete study procedures
- Breastfeeding, pregnancy, or planned pregnancy during the trial
- Any medical condition posing safety risks or interfering with study participation as judged by the Investigator
- Use of any prohibited medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Science 37
Culver City, California, United States, 90230
Actively Recruiting
Research Team
S
Sheila Woodhouse, MD; Ph.D.
CONTACT
J
Jonathan Cotliar, MD; Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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