Comparing Transurethral Microwave Thermotherapy and Prostatic Artery Embolisation for Treating Severe Urinary Symptoms in Men with Enlarged Prostate

What this Trial Is About

Researchers are evaluating two minimally invasive treatments, transurethral microwave thermotherapy TUMT and prostatic artery embolisation PAE, for men with severe lower urinary tract symptoms LUTS caused by benign prostatic hyperplasia BPH. This randomized clinical trial aims to compare the effectiveness of these treatments in reducing urinary symptoms, measured by the International Prostate Symptom Score IPSS six months after the procedures. The study also focuses on patient satisfaction, quality of life, and functional outcomes over the long term. Participants will be assigned to receive either TUMT, which uses microwave energy to destroy prostate tissue through the urethra under local anesthesia, or PAE, which involves blocking blood flow to the prostate via catheter-guided embolisation, also under local anesthesia. Both procedures are usually outpatient with same-day discharge unless hospital admission is required. Catheters are used post-procedure and are typically removed within four weeks based on individual recovery and physician assessment. During the study, participants will undergo regular assessments including symptom questionnaires, uroflowmetry tests, prostate volume measurements, blood tests, and monitoring for side effects or complications. Outcomes will be measured at multiple time points 1, 3, 6, 12, 24, and 60 months after treatment. Researchers will evaluate urinary symptoms, quality of life, sexual function, catheter use, and the need for re-treatment. The study plans to include 220 men aged 40 years or older and will monitor safety and efficacy through these detailed follow-ups.

Clinical Trial on the Effectiveness of TUMT Compared to PAE in Reducing Severe LUTS in Men with BPH