Actively Recruiting
A Clinical Trial on the Efficacy and Safety of TQB6411 for Injection
Led by Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Updated on 2026-05-05
465
Participants Needed
37
Research Sites
144 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To evaluate the efficacy and safety of TQB6411 for Injection in subjects with advanced lung cancer
CONDITIONS
Official Title
A Clinical Trial on the Efficacy and Safety of TQB6411 for Injection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily agree to participate and sign informed consent with good compliance
- Age between 18 and 75 years
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1
- Expected survival longer than 12 weeks
- Have at least one measurable lung cancer lesion per RECIST v1.1 criteria
- Laboratory test results meet specific blood and organ function criteria without recent transfusions or growth factor treatments
- Lung cancer confirmed by histology or cytology
- Willing to provide qualified tumor tissue samples for immunohistochemical testing unless no suitable specimen is available
- Women of childbearing potential must agree to effective contraception during the study and for 6 months after, with a negative pregnancy test before enrollment; men must also agree to use effective contraception during this period
You will not qualify if you...
- History or presence of other malignancies except certain treated cancers with disease-free survival of 5 years or more
- Conditions preventing intravenous injections or blood sampling
- Unresolved adverse reactions from prior treatments above grade 1, except specific mild conditions
- Major surgery or significant injury within 4 weeks before first dose or planned during study
- Serious bleeding events or thromboembolic events within defined recent timeframes
- Active uncontrolled infections such as hepatitis, syphilis, tuberculosis, or lung diseases
- History of mental disorders or psychotropic drug abuse
- Prior or planned bone marrow or organ transplantation
- Significant heart conditions including certain cardiac dysfunctions, arrhythmias, unstable angina, recent heart attack, and long QT syndrome
- Severe infections or immunodeficiency including HIV
- Autoimmune diseases requiring immunosuppressive treatments recently
- Epilepsy needing treatment
- Poorly controlled diabetes
- Recent chemotherapy, immunotherapy, or targeted therapy within 3 weeks prior to first dose
- Tumor conditions such as invasion of major vessels, uncontrolled fluid accumulation, spinal cord compression, or certain brain metastases
- Known allergy to study drug or its ingredients
- Prior treatment with specified targeted antibody-drug conjugates or topoisomerase I inhibitors
- Participation in other antitumor clinical trials within 4 weeks before first dose
- Other conditions that may affect safety or study completion as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 37 locations
1
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100021
Actively Recruiting
2
Beijing Chest Hospital，Capital Medical University
Beijing, Beijing Municipality, China, 101100
Not Yet Recruiting
3
Chongqing University Affiliated Three Gorges Hospital
Chongqing, Chongqing Municipality, China, 404000
Not Yet Recruiting
4
The first affiliated hospital of Guangzhou medical university
Guangzhou, Guangdong, China, 510120
Not Yet Recruiting
5
The first affiliated hospital of Guangzhou medical university
Guanzhou, Guangdong, China, 510120
Not Yet Recruiting
6
Zhongshan City People's Hospital
Zhongshan, Guangdong, China, 528445
Not Yet Recruiting
7
Guangxi Medical University Cancer Hospital
Nanning, Guangxi, China, 53000
Not Yet Recruiting
8
Guangxi Medical University Cancer Hospital
Nanning, Guangxi, China, 53000
Not Yet Recruiting
9
Cangzhou Central hospital
Cangzhou, Hebei, China, 61000
Not Yet Recruiting
10
Cangzhou Central hospital
Cangzhou, Hebei, China, 61000
Not Yet Recruiting
11
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150000
Not Yet Recruiting
12
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150000
Not Yet Recruiting
13
Anyang People's Hospital
Anyang, Henan, China, 455000
Not Yet Recruiting
14
Luoyang Central Hospital (Zhengzhou University Affiliated Luoyang Central Hospital)
Luoyang, Henan, China, 471000
Not Yet Recruiting
15
Nanyang Second General Hospital
Nanyang, Henan, China, 473012
Not Yet Recruiting
16
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China, 430071
Not Yet Recruiting
17
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China, 410000
Not Yet Recruiting
18
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Nanjin, Jiangsu, China, 210019
Not Yet Recruiting
19
Nanjing Drum Tower Hospital
Nanjing, Jiangsu, China, 210000
Not Yet Recruiting
20
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, China, 225000
Not Yet Recruiting
21
Affiliated Zhongshan Hospital Of dalian University
Dalian, Liaoning, China, 116001
Not Yet Recruiting
22
Affiliated Zhongshan Hospital Of dalian University
Dalian, Liaoning, China, 116001
Not Yet Recruiting
23
Liaoning Cancer Research Institute
Shenyang, Liaoning, China, 110000
Not Yet Recruiting
24
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710000
Not Yet Recruiting
25
Shandong First Medical University Affiliated Tumor Hospital
Jinan, Shandong, China, 250117
Not Yet Recruiting
26
Shandong First Medical University Affiliated Tumor Hospital
Jinan, Shandong, China, 250117
Not Yet Recruiting
27
Linyi cancer Hospital
Linyi, Shandong, China, 276034
Not Yet Recruiting
28
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China, 200433
Not Yet Recruiting
29
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China, 200433
Not Yet Recruiting
30
First Hospital of Shangxi Medical University
Taiyuan, Shangxi, China, 030001
Not Yet Recruiting
31
Shanxi Cancer hospital
Taiyuan, Shanxi, China, 030000
Not Yet Recruiting
32
Shanxi Cancer hospital
Taiyuan, Shanxi, China, 030000
Not Yet Recruiting
33
The Second Affiliated Hospital of Air Force Medical University
Xi’an, Shanxi, China, 710000
Not Yet Recruiting
34
Sichuan cancer hosipital
Chengdu, Sichuan, China, 610040
Not Yet Recruiting
35
Tianjin Medical University Cancer Institute & Hospital
Tianjin, Tianjin Municipality, China, 300000
Not Yet Recruiting
36
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Not Yet Recruiting
37
Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, China, 317000
Not Yet Recruiting
Research Team
S
Shengxiang Ren, Doctor
CONTACT
Z
Zhijie Wang, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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