Actively Recruiting
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Led by Merz Therapeutics GmbH · Updated on 2026-05-08
780
Participants Needed
108
Research Sites
131 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this clinical trial, participants with chronic migraine will receive injections with Xeomin or Placebo into muscles of the head and neck. The purpose is to measure the change in monthly migraine days with Xeomin injections compared to Placebo injections. Trial details include: * Trial duration: 52 to 55 weeks; * Screening period: 4 to 5 weeks; * Treatment duration: 4 treatments, each about 12 weeks apart; and * Visit frequency: about every 4 weeks, 14 visits in total. The first and last visit and the 4 treatment visits are on-site, the other 8 visits are remote by phone / video call.
CONDITIONS
Official Title
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of chronic migraine with or without aura for at least 12 months according to International Classification of Headache Disorders Edition 3
- Age under 50 years at migraine onset
- History of at least 15 headache days per month and at least 8 migraine days per month in each of the 3 months prior to screening
- During the last 28 days of screening, at least 15 headache days and 8 migraine days recorded in a headache diary
You will not qualify if you...
- Diagnosis of other primary headache types except tension-type headache
- Diagnosis of aura without headache, migraine with brainstem aura, hemicrania continua, hypnic headache, hemiplegic migraine, retinal migraine, persistent aura without infarction, migraine aura-triggered seizure, or previous migrainous infarction
- Diagnosis of secondary headache types except medication overuse headache
- Taking more than one prescribed drug for migraine prevention
- Stopping anti-CGRP or anti-CGRP receptor monoclonal antibody treatment less than 5 months before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 108 locations
1
TrialSphere Corp, Merz Investigational Site #0010513
Chandler, Arizona, United States, 85286
Actively Recruiting
2
Arizona Neuroscience Research, Merz Investigational Site #0010521
Phoenix, Arizona, United States, 85018
Actively Recruiting
3
Baptist Health Medical Center, Merz Investigational Site #0010520
Little Rock, Arkansas, United States, 72205
Actively Recruiting
4
Chemidox Clinical Trials Inc, Merz Investigational Site #0010488
Lancaster, California, United States, 93534
Actively Recruiting
5
Clinical Research Institute, Merz Investigational Site #0010487
Los Angeles, California, United States, 90048
Actively Recruiting
6
BNL Health, Merz Investigational Site #0010501
Los Angeles, California, United States, 90067
Actively Recruiting
7
Clinical Trials Management Services, Merz Investigational Site #0010526
Thousand Oaks, California, United States, 91360
Actively Recruiting
8
Hasbani Neurology, Merz Investigational Site #0010509
New Haven, Connecticut, United States, 06511
Actively Recruiting
9
Yale Center for Clinical Investigations, Merz Investigational Site #0010527
New Haven, Connecticut, United States, 06519
Actively Recruiting
10
New England Institute Neurology and Headache, Merz Investigational Site #0010441
Stamford, Connecticut, United States, 06905
Actively Recruiting
11
Northwest Florida Clinical Research Group, Merz Investigational Site #0010286
Gulf Breeze, Florida, United States, 32561
Actively Recruiting
12
Nexus Clinical Research Center, Merz Investigational Site #0010514
Homestead, Florida, United States, 33030
Actively Recruiting
13
Jacksonville Center for Clinical Research, Merz Investigational Site #0010515
Jacksonville, Florida, United States, 32216
Actively Recruiting
14
Clinical Research of Central Florida, Merz Investigational Site #0010532
Lakeland, Florida, United States, 33805
Actively Recruiting
15
American Research Institute, Merz Investigational Site #0010492
Miami, Florida, United States, 33157
Actively Recruiting
16
Premiere Research Institute at Palm Beach Neurology, Merz Investigational Site #0010499
West Palm Beach, Florida, United States, 33407
Actively Recruiting
17
Accel Research - NeuroStudies, Merz Investigational Site #0010523
Decatur, Georgia, United States, 30030
Actively Recruiting
18
Hawaii Pacific Neuroscience, Merz Investigational Site #0010510
Honolulu, Hawaii, United States, 96817
Actively Recruiting
19
Kansas Institute of Research,, Merz Investigational Site #0010495
Overland Park, Kansas, United States, 66211
Actively Recruiting
20
Crescent City Headache and Neurology Center, Merz Investigational Site #0010517
Chalmette, Louisiana, United States, 70043
Actively Recruiting
21
DelRicht Clinical Research, Merz Investigational Site #0010518
New Orleans, Louisiana, United States, 70115
Actively Recruiting
22
Sinai Hospital of Baltimore, Merz Investigational Site #0010505
Baltimore, Maryland, United States, 21215
Actively Recruiting
23
MedVadis Research, Merz Investigational Site #0010524
Waltham, Massachusetts, United States, 02451
Actively Recruiting
24
Mass Institute of Clinical Research, Merz Investigational Site #0010506
Westborough, Massachusetts, United States, 01581
Actively Recruiting
25
Vida Clinical Studies, Merz Investigational Site #0010498
Dearborn Heights, Michigan, United States, 48127
Actively Recruiting
26
Quest Research Institute, Merz Investigational Site #0010484
Farmington Hills, Michigan, United States, 48334
Actively Recruiting
27
StudyMetrix Research, Merz Investigational Site #0010530
City of Saint Peters, Missouri, United States, 63303
Actively Recruiting
28
Quality Clinical Research, Merz Investigational Site #0010522
Omaha, Nebraska, United States, 68114
Actively Recruiting
29
Dent Neurosciences Research Center, Merz Investigational Site #0010486
Amherst, New York, United States, 14226
Actively Recruiting
30
Integrative Clinical Trials, Merz Investigational Site #0010496
Brooklyn, New York, United States, 11229
Actively Recruiting
31
New York Neurology Associates, Merz Investigational Site #0010500
New York, New York, United States, 10003
Actively Recruiting
32
True North Neurology, Merz Investigational Site #0010508
Port Jefferson Station, New York, United States, 11776
Actively Recruiting
33
Rochester Clinical Research, Merz Investigational Site #0010512
Rochester, New York, United States, 14609
Actively Recruiting
34
Upstate Clinical Research Associates, Merz Investigational Site #0010485
Williamsville, New York, United States, 14221
Actively Recruiting
35
Dayton Center for Neurological Disorders, Merz Investigational Site #0010531
Centerville, Ohio, United States, 45459
Actively Recruiting
36
Headache Center of Hope, Merz Investigational Site #0010528
Cincinnati, Ohio, United States, 45236
Actively Recruiting
37
University Hospitals Cleveland Medical Center, Merz Investigational Site #0010491
Cleveland, Ohio, United States, 44106
Actively Recruiting
38
Tekton Research, Merz Investigational Site #0010494
Edmond, Oklahoma, United States, 73013
Actively Recruiting
39
Thomas Jefferson University, Merz Investigational Site #0010354
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
40
Coastal Neurology, Merz Investigational Site #0010503
Port Royal, South Carolina, United States, 29935
Actively Recruiting
41
Alina Clinical Trials, Merz Investigational Site #0010511
Dallas, Texas, United States, 75209
Actively Recruiting
42
Lone Star Neurology, Merz Investigational Site #0010497
Frisco, Texas, United States, 75035
Actively Recruiting
43
MedStar Health - Department of Neurology, Merz Investigational Site #0010231
McLean, Virginia, United States, 22101
Actively Recruiting
44
Gershon Pain Specialists, Merz Investigational Site #0010519
Virginia Beach, Virginia, United States, 23454
Actively Recruiting
45
EvergreenHealth Research Department, Merz Investigational Site #0010516
Kirkland, Washington, United States, 98034
Actively Recruiting
46
Gundersen Health System, Merz Investigational Site #0010507
La Crosse, Wisconsin, United States, 54601
Actively Recruiting
47
Medical University of Innsbruck, Merz Investigational Site #0430043
Innsbruck, Austria, 6020
Actively Recruiting
48
Klinikum Klagenfurt Am Wörthersee, Merz Investigational Site #0430042
Klagenfurt, Austria, 9020
Actively Recruiting
49
Genge Partners Inc., Merz Investigational Site #0010525
Montreal, Canada, H4A 3T2
Actively Recruiting
50
CaRe Clinic, Merz Investigational Site #0010504
Red Deer, Canada, T4P 1K4
Actively Recruiting
51
Pratia Brno, Merz Investigational Site #4200053
Brno, Czechia, 602 00
Actively Recruiting
52
Fakultní nemocnice Hradec Králové, Merz Investigational Site #4200056
Hradec Králové, Czechia, 500 05
Actively Recruiting
53
CLINTRIAL, Merz Investigational Site #4200052
Prague, Czechia, 100 00
Actively Recruiting
54
Axon Clinical, Merz Investigational Site #4200051
Prague, Czechia, 150 00
Actively Recruiting
55
Neuropsychiatrie, Merz Investigational Site #4200054
Prague, Czechia, 160 00
Actively Recruiting
56
Rigshospitalet-Glostrup, Merz Investigational Site #0450006
Glostrup Municipality, Denmark, 2600
Actively Recruiting
57
CHU Clermont Ferrand, Merz Investigational Site #0330026
Clermont-Ferrand, France, 63000
Actively Recruiting
58
Centre Hospitalier Universitaire Grenoble Alpes, Merz Investigational Site #0330069
La Tronche, France, 38700
Actively Recruiting
59
CHU Nantes, Merz Investigational Site #0330068
Nantes, France, 44093
Actively Recruiting
60
Charité - Universitätsmedizin Berlin, Merz Investigational Site #0490398
Berlin, Germany, 10117
Actively Recruiting
61
Kopfschmerzzentrum Frankfurt, Merz Investigational Site #0490394
Frankfurt, Germany, 65929
Actively Recruiting
62
Universitätsmedizin Greifswald, Merz Investigational Site #0490397
Greifswald, Germany, 17475
Actively Recruiting
63
Vitos Orthopädische Klinik Kassel, Merz Investigational Site #0490396
Kassel, Germany, 34131
Actively Recruiting
64
Schmerzklinik Kiel GmbH, Merz Investigational Site #0490395
Kiel, Germany, 24149
Actively Recruiting
65
Azienda Ospedaliera Universitaria Careggi, Merz Investigational Site #0390023
Florence, Italy, 50134
Actively Recruiting
66
Ospedale San Raffaele, Merz Investigational Site #0390027
Milan, Italy, 20132
Actively Recruiting
67
Istituto Auxologico Italiano, Merz Investigational Site #0390024
Milan, Italy, 20149
Actively Recruiting
68
Fondazione Istituto Neurologico Nazionale Casimiro Mondino, Merz Investigational Site #0390025
Pavia, Italy, 27100
Actively Recruiting
69
IRCCS San Raffaele Roma, Merz Investigational Site #0390026
Roma, Italy, 00166
Actively Recruiting
70
Centrum Medyczne Neuromed, Merz Investigational Site #0480117
Bydgoszcz, Poland, 85-163
Actively Recruiting
71
AthleticoMed, Merz Investigational Site #0480127
Bydgoszcz, Poland, 85-752
Actively Recruiting
72
ETG Debica, Merz Investigational Site #0480121
Dębica, Poland, 39-200
Actively Recruiting
73
Centrum Medyczne Pratia Gdynia, Merz Investigational Site #0480126
Gdynia, Poland, 81-338
Actively Recruiting
74
Silmedic Sp. z o.o., Merz Investigational Site #0480115
Katowice, Poland, 40-282
Actively Recruiting
75
Jan Banach Research Spot, Merz Investigational Site #0480059
Krakow, Poland, 30-539
Actively Recruiting
76
Pratia MCM, Merz Investigational Site #0480087
Krakow, Poland, 30-727
Actively Recruiting
77
FutureMeds, Merz Investigational Site #0480125
Krakow, Poland, 31-501
Actively Recruiting
78
Krakowska Akademia Neurologii, Merz Investigational Site #0480031
Krakow, Poland, 31-505
Actively Recruiting
79
Neurocor, Merz Investigational Site #0480119
Krakow, Poland, 31-870
Actively Recruiting
80
Clinirem, Merz Investigational Site #0480128
Lublin, Poland, 20-064
Actively Recruiting
81
ETG Lublin, Merz Investigational Site #0480118
Lublin, Poland, 20-412
Actively Recruiting
82
Indywidualna Praktyka Lekarska Dr hab. Med. Anna Szczepańska-Szerej, Merz Investigational Site #0480096
Lublin, Poland, 20-582
Actively Recruiting
83
Instytut Zdrowia dr Boczarska-Jedynak, Merz Investigational Site #0480103
Oświęcim, Poland, 32-600
Actively Recruiting
84
Solumed Centrum Medyczne, Merz Investigational Site #0480122
Poznan, Poland, 60-529
Actively Recruiting
85
ETG Neuroscience, Merz Investigational Site #0480116
Warsaw, Poland, 02-677
Actively Recruiting
86
MIGRE Polskie Centrum Leczenia Migreny, Merz Investigational Site #0480124
Wroclaw, Poland, 52-210
Actively Recruiting
87
Futuremeds, Merz Investigational Site #0480123
Wroclaw, Poland, 53-673
Actively Recruiting
88
ETG Zamosc, Merz Investigational Site #0480120
Zamość, Poland, 22-400
Actively Recruiting
89
MUDr. Beáta Dupejová, neurologická ambulancia, Merz Investigational Site #4210002
Banská Bystrica, Slovakia, 974 04
Actively Recruiting
90
KONZÍLIUM, Merz Investigational Site #4210011
Dubnica nad Váhom, Slovakia, 018 41
Actively Recruiting
91
NEURES, Merz Investigational Site #4210006
Krompachy, Slovakia, 053 42
Actively Recruiting
92
Liptovská nemocnica s poliklinikou, Merz Investigational Site #4210013
Liptovský Mikuláš, Slovakia, 031 23
Actively Recruiting
93
Hospital Clinic de Barcelona-Hospital Plato, Merz Investigational Site #0340047
Barcelona, Spain, 08006
Actively Recruiting
94
Hospital Universitari Vall d'Hebron, Merz Investigational Site #0340006
Barcelona, Spain, 08035
Actively Recruiting
95
Hospital Universitario 12 de Octubre, Merz Investigational Site #0340055
Madrid, Spain, 28041
Actively Recruiting
96
Hospital Universitario La Paz, Merz Investigational Site #0340007
Madrid, Spain, 28046
Actively Recruiting
97
Campus Blua Sanitas Valdebebas Hospital, Merz Investigational Site #0340057
Madrid, Spain, 28055
Actively Recruiting
98
Hospital Regional Universitario de Malaga, Merz Investigational Site #0340050
Málaga, Spain, 29010
Actively Recruiting
99
Hospital Universitario Virgen de la Victoria, Merz Investigational Site #0340056
Málaga, Spain, 29010
Actively Recruiting
100
Hospital Vithas Malaga, Merz Investigational Site #0340054
Málaga, Spain, 29016
Actively Recruiting
101
Hospital Universitario Virgen del Rocio, Merz Investigational Site #0340046
Seville, Spain, 41013
Actively Recruiting
102
Consorci Sanitari de Terrassa, Merz Investigational Site #0340051
Terrassa, Spain, 08227
Actively Recruiting
103
Hospital Universitari i Politecnic La Fe de Valencia, Merz Investigational Site #0340049
Valencia, Spain, 46026
Actively Recruiting
104
Complejo Hospitalario Universitario de Vigo, Merz Investigational Site #0340052
Vigo, Spain, 36312
Actively Recruiting
105
Hospital Viamed Montecanal, Merz Investigational Site #0340053
Zaragoza, Spain, 50012
Actively Recruiting
106
Inselspital Bern, Merz Investigational Site #0410003
Bern, Switzerland, 3010
Actively Recruiting
107
Kopfwehzentrum Hirslanden, Merz Investigational Site #0410017
Zollikon, Switzerland, 8702
Actively Recruiting
108
Royal Stoke University Hospital, Merz Investigational Site #0440048
Stoke-on-Trent, United Kingdom, ST4 6QG
Actively Recruiting
Research Team
P
Public Disclosure Manager
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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