Actively Recruiting
A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Prediabetes or Type 2 Diabetes
Led by QuickSilver Scientific · Updated on 2026-03-16
90
Participants Needed
1
Research Sites
29 weeks
Total Duration
On this page
Sponsors
Q
QuickSilver Scientific
Lead Sponsor
K
KGK Science Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a randomized, single-blind, controlled, parallel clinical trial to examine the efficacy and safety of AMPK Charge+® with and without use of semaglutide on glycemic response in adults with prediabetes or Type 2 Diabetes. The main question it aims to answer is: What is the difference in change in fasting blood glucose and insulin, and hemoglobin A1c (HbA1c) from baseline at Day 84 between AMPK Charge+® and AMPK Charge+® with semaglutide? Participants will consume AMPK Charge+® with or without semaglutide injections and will be evaluated for glycemic response parameters.
CONDITIONS
Official Title
A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Prediabetes or Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Females not able to have children due to sterilization or menopause for at least 1 year, or females of child-bearing potential with a negative pregnancy test and using approved birth control methods for the study duration
- Adults eligible for semaglutide therapy but not currently taking it, including treatment-naïve prediabetes (HbA1c 6.0-6.5%) and Type 2 Diabetes (HbA1c 6.5-7.5%) with metformin contraindication or intolerance
- Stable body weight with less than 5 kg change in the past 3 months
- Willing to maintain current lifestyle habits including diet, physical activity, medications, supplements, sleep, and use of nicotine, tobacco, or cannabinoid products throughout the study
- Willing to complete study questionnaires, diaries, and clinic visits
- Provided written informed consent to participate
You will not qualify if you...
- Pregnant, breastfeeding, or planning pregnancy during the study
- Allergy, sensitivity, intolerance, or dietary restrictions preventing use of study products
- Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2
- Unstable metabolic or chronic diseases
- Current or past significant gastrointestinal diseases
- Unstable hypertension (stable medication dose for at least 3 months may be considered)
- Type 1 diabetes or diabetic ketoacidosis
- Significant cardiovascular event in past 6 months (stable medication may be considered)
- Kidney or liver diseases, except symptom-free history of kidney stones for 6 months
- Thyroid condition requiring medication (stable dose for at least 3 months may be considered)
- Major surgery in past 3 months or planned surgery during study (minor surgery considered case-by-case)
- Cancer except fully excised basal cell carcinoma or cancer in remission for over 5 years
- Autoimmune disease or immune compromised
- HIV, Hepatitis B or C infection
- Blood or bleeding disorders
- Alcohol intake averaging more than 2 standard drinks per day
- Alcohol or drug abuse within last 12 months
- Use of medications, supplements, or foods affecting study product efficacy or safety
- Abnormal lab results at screening
- Blood donation within 30 days before, during, or planned within 30 days after study
- Participation in another clinical trial within 30 days before baseline
- Unable to give informed consent
- Any other condition or lifestyle factor that may affect study participation or safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
KGK Science Inc.
London, Ontario, Canada, N6B3L1
Actively Recruiting
Research Team
M
Marc Moulin, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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