Actively Recruiting
A Clinical Trial of Extended (High) Treatment Dose Antibiotics in Combination With Methenamine Hippurate Compared to the Standard of Care (Either Prophylactic (Low) Dose Antibiotic Treatment or Methenamine Hippurate) in Females With Chronic Urinary Tract Infection
Led by University College, London · Updated on 2026-04-23
192
Participants Needed
5
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic Urinary Tract Infection (UTI) is a type of UTI where symptoms are constant and occur every day, unlike recurrent UTIs, which come and go with symptom-free breaks in between. Current treatment for chronic UTI within the NHS is based on recommended guidelines for recurrent UTI. The standard approach typically includes one of the following treatments: * Long-term, prophylactic (low) dose daily antibiotic (where medication is used at low doses to try to prevent symptoms reoccurring). * Long-term use of a urinary antiseptic (which helps keep your urine bacteria free), called methenamine hippurate. These often do not work for people with chronic UTI, and symptoms can persist. Moreover, standard urine tests may fail to detect infections, making diagnosis and treatment more challenging. The EAT-UP trial will investigate whether longer courses of treatment (higher) dose antibiotics combined with methenamine hippurate (a urinary antiseptic) are a more effective treatment at reducing levels of infection and symptoms than standard of care treatments (as described above).
CONDITIONS
Official Title
A Clinical Trial of Extended (High) Treatment Dose Antibiotics in Combination With Methenamine Hippurate Compared to the Standard of Care (Either Prophylactic (Low) Dose Antibiotic Treatment or Methenamine Hippurate) in Females With Chronic Urinary Tract Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18 years or older
- Diagnosed with chronic UTI with daily symptoms affecting urinary storage and pain for at least 3 months
- Fresh urine test showing 20 or more white blood cells per microliter at screening
- Estimated glomerular filtration rate (eGFR) of 45 ml/min/1.73m2 or higher
- Able and willing to attend all trial visits and follow study procedures
- Able and willing to provide informed consent before any study assessments
- No structural or functional urinary tract abnormalities such as kidney reflux, catheter use, renal transplant, diversion surgery, renal stones, significant prolapse, or incomplete bladder emptying
You will not qualify if you...
- Unable to take cefalexin, nitrofurantoin, or trimethoprim at required doses due to medical reasons
- Unable to take methenamine hippurate due to medical contraindications
- Currently using immune-modulating drugs for conditions like rheumatoid arthritis, chronic lung disease, autoimmune diseases, or cancer
- Using Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
- Diagnosed with bladder cancer
- Active or recent sexually transmitted infection within 3 months
- Used treatment-dose antibiotics for more than 14 consecutive days for UTI in the last 3 months
- Pregnant, planning pregnancy during the trial, or breastfeeding
- Women of childbearing potential unwilling or unable to use acceptable contraception during the trial and for 1 week after
- Participating or recently participated in another clinical trial within 6 months
- Any medical condition or previous treatment judged by the investigator to affect ability to participate
- Taken SGLT2 inhibitors within 24 hours before screening visit
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
Not Yet Recruiting
2
University College London Hospital (UCLH), UCLH NHS Foundation Trust
London, United Kingdom
Not Yet Recruiting
3
Whittington Hospital, Whittington Health NHS Trust
London, United Kingdom
Actively Recruiting
4
St Mary's Hospital, Manchester University NHS Foundation Trust
Manchester, United Kingdom
Not Yet Recruiting
5
Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Actively Recruiting
Research Team
E
EAT-UP Trial Team
CONTACT
L
Liz Deane
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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