Actively Recruiting
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Led by EyeBiotech Ltd. · Updated on 2026-05-04
960
Participants Needed
30
Research Sites
118 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
CONDITIONS
Official Title
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Who Can Participate
Eligibility Criteria
You may qualify if you...
The main inclusion criteria include but are not limited to the following:
- Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye)
- The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment
The main exclusion criteria include but are not limited to the following
- Has uncontrolled blood pressure at screening
- History of any prior macular laser photocoagulation in the study eye
- History of uveitis in either eye
- History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study
- Has uncontrolled glaucoma in the study eye
- Active retinal disease other than the condition under investigation in the study eye
- Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 30 locations
1
Retina Partners of Northwest Arkansas, PLLC
Springdale, Arkansas, United States, 72764
Actively Recruiting
2
Global Research Management, Inc.
Glendale, California, United States, 91204
Actively Recruiting
3
Retinal Consultants Medical Group (Site 024)
Modesto, California, United States, 95356
Actively Recruiting
4
Retina Consultants of Southern California (Site 043)
Redlands, California, United States, 92374
Actively Recruiting
5
Retinal Consultants Medical Group (Site 020)
Sacramento, California, United States, 95825
Actively Recruiting
6
Retinal Consultants Medical Group (Site 022)
Sacramento, California, United States, 95841
Actively Recruiting
7
Retina Group of Florida (Site 070)
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
8
Fort Lauderdale Eye Institute (Site 042)
Plantation, Florida, United States, 33324
Actively Recruiting
9
Retina Vitreous Associates of Florida (Site 049)
St. Petersburg, Florida, United States, 33711
Actively Recruiting
10
Retina Associates of Florida, LLC
Tampa, Florida, United States, 33609
Actively Recruiting
11
Retina Vitreous Associates of Florida
Tampa, Florida, United States, 33617
Actively Recruiting
12
Illinois Retina Associates
Oak Park, Illinois, United States, 60304
Actively Recruiting
13
Cumberland Valley Retina Consultants (Site 007)
Hagerstown, Maryland, United States, 21740
Actively Recruiting
14
Foundation for Vision Research (Site 073)
Grand Rapids, Michigan, United States, 49546
Actively Recruiting
15
Mississippi Retina Associates (Site 084)
Madison, Mississippi, United States, 39110
Actively Recruiting
16
ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)
Hauppauge, New York, United States, 11788
Actively Recruiting
17
Retina Vitreous Surgeons of CNY, PC (Site 033)
Liverpool, New York, United States, 13088
Actively Recruiting
18
Tulsa Retina Consultants
Tulsa, Oklahoma, United States, 74114
Actively Recruiting
19
EyeHealth Northwest
Portland, Oregon, United States, 97225
Actively Recruiting
20
Palmetto Retina Center
Aiken, South Carolina, United States, 29803
Actively Recruiting
21
Charleston Neuroscience Institute - Bluffton (Site 124)
Bluffton, South Carolina, United States, 29910
Actively Recruiting
22
Charleston Neuroscience Institute (Site 104)
Charleston, South Carolina, United States, 29414
Actively Recruiting
23
Retina Research Institute of Texas (Site 010)
Abilene, Texas, United States, 79606
Actively Recruiting
24
Austin Research Center for Retina
Austin, Texas, United States, 78705
Actively Recruiting
25
Austin Retina Associates (Site 012)
Austin, Texas, United States, 78705
Actively Recruiting
26
Texas Retina (Site 037)
Plano, Texas, United States, 75075
Actively Recruiting
27
Retina Consultants of Texas (Site 014)
The Woodlands, Texas, United States, 77384
Actively Recruiting
28
Retina Associates of Utah
Salt Lake City, Utah, United States, 84107
Actively Recruiting
29
Piedmont Eye Center (Site 054)
Lynchburg, Virginia, United States, 24502
Actively Recruiting
30
Pacific Northwest Retina (Site 112)
Burlington, Washington, United States, 98233
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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