Actively Recruiting
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Led by EyeBiotech Ltd. · Updated on 2026-05-04
960
Participants Needed
9
Research Sites
119 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
CONDITIONS
Official Title
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye)
- The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment
- Age 50 years or older
You will not qualify if you...
- Has uncontrolled blood pressure at screening
- History of any prior macular laser photocoagulation in the study eye
- History of uveitis in either eye
- History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study
- Has uncontrolled glaucoma in the study eye
- Active retinal disease other than the condition under investigation in the study eye
- Has previously received anti-vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Northern California Retina Vitreous Associates Medical Group, Inc.
Mountain View, California, United States, 94040
Actively Recruiting
2
University Retina & Macula Associates, P.C.
Lemont, Illinois, United States, 60439
Actively Recruiting
3
Mid Atlantic Retina Specialists
Hagerstown, Maryland, United States, 21740
Actively Recruiting
4
Retina Consultants of Minnesota
Edina, Minnesota, United States, 55435
Actively Recruiting
5
Envision Ocular, LLC
Bloomfield, New Jersey, United States, 07003
Actively Recruiting
6
Erie Retina Research
Erie, Pennsylvania, United States, 16505
Actively Recruiting
7
Charleston Neuroscience Institute
Ladson, South Carolina, United States, 29456
Actively Recruiting
8
Retina Consultants of Texas
Bellaire, Texas, United States, 77401
Actively Recruiting
9
Pacific Northwest Retina
Bellevue, Washington, United States, 98004
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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