Actively Recruiting
Clinical Trial Comparing Low-volume Sprint Interval Training and Moderate-intensity Continuous Training to Reduce Ambulatory Blood Pressure in Adults with Hypertension
Led by Unidad Enfermedades Cardiometabolicas- Hospital Interzonal General Agudos San Martin de La Plata · Updated on 2025-11-14
20
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating two types of exercise programs for adults aged 30 to 59 with arterial hypertension but without high cardiovascular risk. The study compares Sprint Interval Training (SIT), which involves short bursts of maximum effort, with Moderate-Intensity Continuous Training (MICT). The main goal is to see how each exercise type affects 24-hour ambulatory systolic blood pressure after 12 weeks of training. Secondary goals include assessing other blood pressure measures, metabolic factors, body composition, and blood markers like IL-6 and alpha-CGRP. Participants first complete a two-week familiarization period before being randomly assigned to one of two exercise groups. The MICT group cycles continuously at moderate intensity (50-70% of maximum oxygen uptake) for 15 to 30 minutes per session. The SIT group performs 2 to 4 maximal cycling sprints lasting 20-30 seconds each, with recovery breaks, totaling up to 15 minutes per session. Both groups train three times per week for 12 weeks under professional supervision, with monitoring of blood pressure, heart rate, and oxygen levels during sessions. During the study, participants undergo evaluations before and after the exercise period. These include ambulatory and office blood pressure monitoring, body measurements, blood tests for metabolic and inflammatory markers, heart and vessel function assessments, and physical fitness tests. The study tracks adherence to training and examines changes in various health parameters to understand the effects of both exercise programs on hypertension. The total participation lasts about 14 weeks, including familiarization and intervention phases.
CONDITIONS
Brief Title
Clinical Trial in Hypertensive Patients Comparing Two Cardiorespiratory Exercise Protocols, Low-volume Sprint Interval Training (SIT) Versus Moderate-intensity Continuous Training (MICT), to Evaluate Decreases in Ambulatory Blood Pressure and Other Clinical Variables.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of both sexes between 30 and 59 years old with diagnosed hypertension
- Hypertension defined by history of hypertension under treatment or average blood pressure levels ≥140/90 mmHg without treatment
- Body mass index (BMI) between 18.5 and 34.9 kg/m²
You will not qualify if you...
- Body mass index (BMI) less than 18.5 or greater than or equal to 35
- Office blood pressure readings of 160/100 mmHg or higher
- High cardiovascular risk conditions such as type II diabetes, chronic kidney disease with eGFR less than 60 mL/min, cerebrovascular disease, coronary artery disease, peripheral arterial disease, or heart failure
- Pregnant or postpartum women up to 3 months postpartum
- Psychophysical limitations preventing exercise
- History of active malignant cancer under treatment
- Pharmacological treatment for hypertension started or changed during the 3-month follow-up period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 weeks
Participants undergo a 2-week familiarization phase before starting the exercise programs.
Multiple visits during the familiarization period
Duration - 12 weeks
Participants follow one of two exercise protocols: Low-volume Sprint Interval Training (SIT) or Moderate-intensity Continuous Training (MICT), training three times per week under professional supervision.
Three supervised visits per week for 12 weeks
Duration - 1 to 2 weeks
Participants undergo assessments including ambulatory blood pressure monitoring, anthropometry, laboratory tests, hemodynamic measurements, exercise testing, and strength evaluation after completing the exercise program.
1 to 2 visits (in-person)
Trial Site Locations
Total: 1 location
1
Hospital Interzonal General San Martin La Plata
La Plata, Buenos Aires, Argentina, 1900
Actively Recruiting
Research Team
J
Julian Minetto, Physican
W
Walter Espeche, Doctor (PH)
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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