Actively Recruiting
Clinical Trial in Hypertensive Patients Comparing Two Cardiorespiratory Exercise Protocols, Low-volume Sprint Interval Training (SIT) Versus Moderate-intensity Continuous Training (MICT), to Evaluate Decreases in Ambulatory Blood Pressure and Other Clinical Variables.
Led by Unidad Enfermedades Cardiometabolicas- Hospital Interzonal General Agudos San Martin de La Plata · Updated on 2025-11-14
20
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized clinical trial aims to compare two cardiorespiratory exercise training protocols - Sprint Interval Training (SIT), characterized by short, maximal-intensity efforts, versus Moderate-Intensity Continuous Training (MICT) - in patients with arterial hypertension. The primary objective is to evaluate the impact of both interventions on 24-hour ambulatory systolic blood pressure (ABPM) after a 12-week training period. Secondary outcomes include diastolic, daytime, and nighttime blood pressure, metabolic and hemodynamic parameters, body composition, and serum myokine levels (IL-6 and α-CGRP). Participants aged 30-59 years with diagnosed hypertension but without high cardiovascular risk will be recruited from the Cardio-Metabolic Disease Unit of Hospital San Martín (La Plata, Argentina). After a two-week familiarization period, eligible participants will be randomized to SIT or MICT groups. The intervention will last 12 weeks, with three supervised sessions per week. The study will provide valuable information about the effectiveness, safety, and clinical applicability of brief, high-intensity exercise for blood pressure control in hypertensive patients.
CONDITIONS
Official Title
Clinical Trial in Hypertensive Patients Comparing Two Cardiorespiratory Exercise Protocols, Low-volume Sprint Interval Training (SIT) Versus Moderate-intensity Continuous Training (MICT), to Evaluate Decreases in Ambulatory Blood Pressure and Other Clinical Variables.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of both sexes between 30-59 years of age who meet the definition of hypertension.
- History of hypertension with current pharmacological treatment (ACE inhibitors, angiotensin II receptor antagonists, calcium channel blockers, thiazide diuretics, or beta blockers).
- Patients with hypertension diagnosed by average blood pressure 140/90 mmHg without pharmacological treatment at evaluation.
You will not qualify if you...
- Body mass index (BMI) less than 18.5 or greater than 35.
- Office blood pressure readings 160/100 mmHg.
- High cardiovascular risk conditions including type II diabetes, chronic kidney disease (eGFR <60 mL/min), cerebrovascular disease, coronary artery disease, peripheral arterial disease, or heart failure diagnosed by Framingham criteria.
- Pregnant women or postpartum up to 3 months.
- Psychophysical limitations that impair exercise ability.
- History of active cancer under treatment.
- Changes or initiation of pharmacological treatment during the 3-month follow-up.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Interzonal General San Martin La Plata
La Plata, Buenos Aires, Argentina, 1900
Actively Recruiting
Research Team
J
Julian Minetto, Physican
CONTACT
W
Walter Espeche, Doctor (PH)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here