Actively Recruiting
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
Led by Novartis Pharmaceuticals · Updated on 2026-05-14
407
Participants Needed
65
Research Sites
281 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicentre, randomized, double-blind, placebo-controlled, parallel group Phase II study to evaluate the efficacy and safety of VHB937 in participants with early AD followed by an Extension. The double-blind part is 72 weeks long, followed by an extension.
CONDITIONS
Official Title
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female participants 50 to 85 years of age
- Diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer's disease or mild Alzheimer's disease
- Clinical Dementia Rating (CDR) Global score of 0.5 or 1.0
- Confirmation of Alzheimer's disease based on cerebrospinal fluid biomarkers or amyloid PET imaging
- Reliable study partner who can accompany the participant at study visits
- If on symptomatic Alzheimer's treatment (AChEIs/memantine), on a stable dose prior to starting study treatment
You will not qualify if you...
- Dementia due to conditions other than Alzheimer's disease, including frontal temporal dementia, Parkinson's disease, dementia with Lewy bodies, Huntington disease, vascular dementia
- History or current diagnosis of cardiac conditions or ECG abnormalities indicating significant safety risk
- Transient ischemic attacks (TIA) or stroke within 12 months
- Clinical evidence of liver or kidney disease or injury
- Current major depressive episode not adequately controlled, history of schizophrenia or other chronic psychosis
- Significant neurological disease other than dementia, such as serious brain infection, traumatic brain injury, multiple concussions, epilepsy, or recurrent seizures
- Suicidal thoughts within 6 months or behavior within 2 years before screening
- Presence of cancer, HIV, hepatitis B or C, uncontrolled thyroid disease, or uncontrolled diabetes
- Taking any prohibited medications
- Other protocol-defined inclusion or exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 65 locations
1
Banner Alzheimers Institute
Phoenix, Arizona, United States, 85006
Actively Recruiting
2
Irvine Center for Clinical Research
Irvine, California, United States, 92618
Actively Recruiting
3
University of California San Diego
La Jolla, California, United States, 92037
Actively Recruiting
4
University of California at Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
5
Jem Research Institute
Atlantis, Florida, United States, 33462-6608
Actively Recruiting
6
Visionary Investigators Network
Aventura, Florida, United States, 33180
Actively Recruiting
7
K2 Medical Research LLC
Maitland, Florida, United States, 32751
Actively Recruiting
8
K2 Medical Research LLC
Maitland, Florida, United States, 32751
Actively Recruiting
9
Renstar Medical Research
Ocala, Florida, United States, 34471
Actively Recruiting
10
Charter Research The Villages
The Villages, Florida, United States, 32162
Actively Recruiting
11
Alzheimers Research Treatment Ctr
Wellington, Florida, United States, 33414
Actively Recruiting
12
Alzheimers Research Treatment Ctr
Wellington, Florida, United States, 33414
Actively Recruiting
13
Conquest Research
Winter Park, Florida, United States, 32789
Actively Recruiting
14
Hawaii Pacific Neuroscience LLC
Honolulu, Hawaii, United States, 96817
Actively Recruiting
15
University of Kansas Hospital
Fairway, Kansas, United States, 66205
Actively Recruiting
16
ActivMed Practices and Research
Methuen, Massachusetts, United States, 01844
Actively Recruiting
17
Citizens Memorial Hospital Neurology CLinic
Bolivar, Missouri, United States, 65613
Actively Recruiting
18
Lou Ruvo Center for Brain Health
Las Vegas, Nevada, United States, 89106
Actively Recruiting
19
UNC Hosp Invest Drug Serv Pharm
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
20
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
21
Neural Net Research
Portland, Oregon, United States, 97225
Actively Recruiting
22
Abington Neurological Associates Ltd
Willow Grove, Pennsylvania, United States, 19090
Actively Recruiting
23
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229-3900
Actively Recruiting
24
University of Washington Medical Center
Seattle, Washington, United States, 98195
Actively Recruiting
25
Novartis Investigative Site
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
26
Novartis Investigative Site
Kogarah, New South Wales, Australia, 2217
Actively Recruiting
27
Novartis Investigative Site
Box Hill, Victoria, Australia, 3128
Actively Recruiting
28
Novartis Investigative Site
London, Ontario, Canada, N6G 3H7
Actively Recruiting
29
Novartis Investigative Site
North York, Ontario, Canada, M6A 2C8
Actively Recruiting
30
Novartis Investigative Site
Toronto, Ontario, Canada, M3B 2S7
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31
Novartis Investigative Site
Toronto, Ontario, Canada, M5T 2S8
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32
Novartis Investigative Site
Brno, Czechia, 602 00
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33
Novartis Investigative Site
Prague, Czechia, 160 00
Actively Recruiting
34
Novartis Investigative Site
Toulouse, Haute Garonne, France, 31059
Actively Recruiting
35
Novartis Investigative Site
Paris, France, 75013
Actively Recruiting
36
Novartis Investigative Site
Berlin, Germany, 12200
Actively Recruiting
37
Novartis Investigative Site
Berlin, Germany, 13353
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38
Novartis Investigative Site
München, Germany, 80377
Actively Recruiting
39
Novartis Investigative Site
Cefalù, PA, Italy, 90015
Actively Recruiting
40
Novartis Investigative Site
Perugia, PG, Italy, 06129
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41
Novartis Investigative Site
Itabashi Ku, Tokyo, Japan, 1730015
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42
Novartis Investigative Site
Kodaira, Tokyo, Japan, 187-8551
Actively Recruiting
43
Novartis Investigative Site
Shinjuku Ku, Tokyo, Japan, 160-0023
Actively Recruiting
44
Novartis Investigative Site
Amsterdam, Netherlands, 1081 GN
Actively Recruiting
45
Novartis Investigative Site
Bialystok, Poland, 15-756
Actively Recruiting
46
Novartis Investigative Site
Oświęcim, Poland, 32-600
Actively Recruiting
47
Novartis Investigative Site
Wroclaw, Poland, 53659
Actively Recruiting
48
Novartis Investigative Site
Seoul, Korea, South Korea, 05505
Actively Recruiting
49
Novartis Investigative Site
Incheon, South Korea, 21565
Actively Recruiting
50
Novartis Investigative Site
Incheon, South Korea, 22332
Actively Recruiting
51
Novartis Investigative Site
Seoul, South Korea, 03080
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52
Novartis Investigative Site
Seoul, South Korea, 04763
Actively Recruiting
53
Novartis Investigative Site
Seoul, South Korea, 05030
Actively Recruiting
54
Novartis Investigative Site
Pamplona, Navarre, Spain, 31008
Actively Recruiting
55
Novartis Investigative Site
Valencia, Valencia, Spain, 46017
Actively Recruiting
56
Novartis Investigative Site
Valencia, Spain, 46026
Actively Recruiting
57
Novartis Investigative Site
Mölndal, Sweden, 431 80
Actively Recruiting
58
Novartis Investigative Site
Stockholm, Sweden, 141 86
Actively Recruiting
59
Novartis Investigative Site
Edinburgh, Lothian, United Kingdom, EH12 5PJ
Actively Recruiting
60
Novartis Investigative Site
Aberdeen, United Kingdom, AB25 2ZH
Actively Recruiting
61
Novartis Investigative Site
London, United Kingdom, SE5 8AF
Actively Recruiting
62
Novartis Investigative Site
London, United Kingdom, W1G 9JF
Actively Recruiting
63
Novartis Investigative Site
London, United Kingdom, WC1N 3BG
Actively Recruiting
64
Novartis Investigative Site
Newcastle upon Tyne, United Kingdom, NE4 6BE
Actively Recruiting
65
Novartis Investigative Site
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
Research Team
N
Novartis Pharmaceuticals
CONTACT
N
Novartis Pharmaceuticals
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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