Actively Recruiting
A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases
Led by Western University, Canada · Updated on 2025-07-20
30
Participants Needed
1
Research Sites
254 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Testicular cancer represents 1% of adult neoplasms and is the most common solid malignancy in young men. At diagnosis, approximately 90% of cases are germ cell tumours (GCT), categorised as either seminoma (55-60%) or non-seminoma types (40-45%). For many years, the management of patients with CS IIA/B seminoma and retroperitoneal lymph node involvement ≤ 3 cm are eligible for treatment with either radiotherapy or chemotherapy Despite high cure rates for CS II seminoma (approximately 90%) with chemotherapy or radiotherapy, concerns persist regarding short and long-term treatment-related toxicities (such as increased risks of cardiovascular disease and secondary malignancies As such, an alternative strategy which has been explored in this study is the role of RPLND for the management of these patients
CONDITIONS
Official Title
A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (>18 years) with pure seminoma confirmed by orchiectomy.
- Clinical stage I with retroperitoneal relapse or de novo clinical stage II at presentation.
- Imaging showing no more than 2 enlarged retroperitoneal lymph nodes, each ≤3 cm, within 8 weeks before surgery.
- Suitable for bilateral nerve-sparing RPLND surgery.
- Normal serum tumor markers (AFP, HCG, LDH) within 2 weeks before surgery.
You will not qualify if you...
- Any medical condition making surgery too risky as judged by the surgeon.
- Presence of any non-seminoma component in the orchiectomy specimen.
- AFP level above 20 at any time before or after orchiectomy.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
London Health Sciences Centre
London, Ontario, Canada
Actively Recruiting
Research Team
K
Kaydee Connors
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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