Trial Comparing Targeted vs Standard Antibiotic Prevention to Reduce Infections After Bladder Removal Surgery

What this Trial Is About

Researchers are evaluating whether postoperative antibiotics targeted to bacteria found in urine can reduce infections after bladder removal surgery cystectomy compared to a standard antibiotic approach. This trial focuses on patients undergoing cystectomy, a surgery with a high risk of infection and readmission within 90 days. The study aims to improve recovery by testing a more personalized antibiotic strategy against the current standard treatment. Participants will be randomly assigned to one of two groups after surgery one group will receive a standard antibiotic called pivmecillinam taken three times on the day of ureteral stent removal, while the other group will receive a single-day targeted antibiotic based on bacteria detected in a postoperative urine sample. If no bacteria are found, no antibiotics will be given. All other care before, during, and after surgery will follow usual hospital guidelines. During the 90-day follow-up, participants will provide urine samples and complete quality of life questionnaires before and after surgery. Researchers will collect data on infection-related hospital readmissions, complications, and antibiotic use from medical records. The main goal is to see if the targeted antibiotic reduces infections leading to readmission within 90 days. The study includes detailed monitoring and plans for early analysis to ensure participant safety and study effectiveness.

Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis