Actively Recruiting
A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
Led by Hoffmann-La Roche · Updated on 2026-05-11
800
Participants Needed
150
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the efficacy and safety of trontinemab in participants with early symptomatic Alzheimer's disease (AD) (mild cognitive impairment \[MCI\] to mild dementia due to AD).
CONDITIONS
Official Title
A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willingness and ability to complete all aspects of the study, including MRI, clinical genotyping, and PET imaging or cerebrospinal fluid testing
- Adequate vision and hearing to perform neuropsychological testing, with aids allowed
- Evidence of Alzheimer's disease pathology confirmed by amyloid PET scan or cerebrospinal fluid tau181/A2 ratio
- Diagnosis of probable Alzheimer's dementia or mild cognitive impairment due to Alzheimer's disease (clinical Stage 3 or 4)
- Mini-Mental State Examination (MMSE) score of 22 or higher and Clinical Dementia Rating-Global Score of 0.5 or 1.0
- History of gradual cognitive decline over the last year reported by participant or informant
- Repeatable Battery for the Assessment of Neuropsychological Status Delayed Memory Index score of 85 or higher
- Availability of a study partner as defined by the protocol
You will not qualify if you...
- Any condition other than Alzheimer's disease that may affect cognition
- History or presence of clinically significant cerebrovascular disease
- History of severe central nervous system trauma causing persistent neurological deficit or brain damage
- History or presence of significant intracranial mass
- MRI evidence of significant brain abnormalities or inability to tolerate or contraindication to MRI
- Unstable or uncontrolled medical conditions that could affect safety or study assessments
- History of malignancy except if cured or with negligible risk of spread or death
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 150 locations
1
Banner Alzheimer?s Institute
Phoenix, Arizona, United States, 85006
Actively Recruiting
2
Sun Valley Research Center, Inc.
Imperial, California, United States, 92251
Actively Recruiting
3
Healthy Brain Clinic
Long Beach, California, United States, 90804
Actively Recruiting
4
Oakland Clinical
Oakland, California, United States, 94609
Actively Recruiting
5
Riverside Clinical
Riverside, California, United States, 92506
Actively Recruiting
6
Cenexel California Neuroscience Research, LLC
Sherman Oaks, California, United States, 91403
Actively Recruiting
7
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
8
JEM Research LLC
Atlantis, Florida, United States, 33462
Actively Recruiting
9
K2 Medical Research-Winter Garden
Clermont, Florida, United States, 34711
Actively Recruiting
10
Visionary Investigators Network- Neurology Aventura
Miami, Florida, United States, 33133
Actively Recruiting
11
Charter Research - Winter Park/Orlando
Orlando, Florida, United States, 32803
Actively Recruiting
12
Conquest Research - Lake Nona
Orlando, Florida, United States, 32832
Actively Recruiting
13
Alzheimer's Research and Treatment Center
Stuart, Florida, United States, 34997
Actively Recruiting
14
CenExel iResearch, LLC
Decatur, Georgia, United States, 30030
Actively Recruiting
15
Center for Advanced Research & Education
Gainesville, Georgia, United States, 30501
Actively Recruiting
16
Great Lakes Clinical Trials Chicago d/b/a Flourish Research Andersonville
Chicago, Illinois, United States, 60640
Actively Recruiting
17
Adams Clinical Boston
Boston, Massachusetts, United States, 02116
Actively Recruiting
18
Adams Clinical Watertown
Watertown, Massachusetts, United States, 02472
Actively Recruiting
19
Quest Research Institute
Farmington Hills, Michigan, United States, 48334
Actively Recruiting
20
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198-8440
Actively Recruiting
21
The Cognitive and Research Center of New Jersey
Springfield, New Jersey, United States, 07081
Actively Recruiting
22
IMA Clinical Research - Albuquerque
Albuquerque, New Mexico, United States, 87109
Actively Recruiting
23
AD-CARE, University of Rochester Medical Center
Rochester, New York, United States, 14620
Actively Recruiting
24
Summit Research Network Inc.
Portland, Oregon, United States, 97210
Actively Recruiting
25
Flourish Research ? Philadelphia
Plymouth Meeting, Pennsylvania, United States, 19462
Actively Recruiting
26
Palmetto Clinical Trials
Summerville, South Carolina, United States, 29485
Actively Recruiting
27
Gadolin Research, LLC
Beaumont, Texas, United States, 77702
Actively Recruiting
28
Kerwin Medical Center
Dallas, Texas, United States, 75216
Actively Recruiting
29
Re:Cognition Health - Fort Worth
Fort Worth, Texas, United States, 76104
Actively Recruiting
30
Mt.Olympus Medical Research
Katy, Texas, United States, 77450
Actively Recruiting
31
El Faro Health and Therapeutics
Rio Grande City, Texas, United States, 78582
Actively Recruiting
32
Sana Research, LLC
Arlington, Virginia, United States, 22205
Actively Recruiting
33
Re:Cognition Health
Fairfax, Virginia, United States, 22031
Actively Recruiting
34
INECO Neurociencias Orono
Rosario, Santa Fe Province, Argentina, S2000DTC
Actively Recruiting
35
CIER
C. A. B. A., Argentina, C1055AAF
Actively Recruiting
36
Fundacion Scherbovsky
Mendoza, Argentina, 5500
Actively Recruiting
37
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
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38
Southern Neurology
Kogarah, New South Wales, Australia, 2217
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39
KaRa Institute of Neurological Diseases
Macquarie Park, New South Wales, Australia, 2113
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40
Flinders Medical Centre
Bedford Park, South Australia, Australia, 5042
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41
Queen Elizabeth Hospital
Woodville, South Australia, Australia, 5011
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42
Box Hill Hospital
Box Hill, Victoria, Australia, 3128
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43
Austin Health
Heidelberg, Victoria, Australia, 3084
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44
Alfred Hospital
Melbourne, Victoria, Australia, 3004
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45
Alzheimer?s Research Australia
Nedlands, Western Australia, Australia, 6009
Actively Recruiting
46
L2 Ip Instituto de Pesquisas Clinicas Ltda ME
Brasília, Federal District, Brazil, 70200-730
Actively Recruiting
47
Instituto de Neurologia de Curitiba
Curitiba, Paraná, Brazil, 81210-310
Actively Recruiting
48
Clinica Clinilive ltda
Maringá, Paraná, Brazil, 87013-250
Actively Recruiting
49
Instituto do Cerebro do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
Actively Recruiting
50
Clinica Neurologica
Joinville, Santa Catarina, Brazil, 89202-190
Actively Recruiting
51
CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo do Campo, São Paulo, Brazil, 09715-090
Actively Recruiting
52
Okanagan Clinical Trials
Kelowna, British Columbia, Canada, V1Y 1Z9
Actively Recruiting
53
Centricity Research
Halifax, Nova Scotia, Canada, B3S 1N2
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54
Parkwood Institute Main Building
London, Ontario, Canada, N6C0A7
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55
The Ottawa Memory Clinic
Ottawa, Ontario, Canada, K1Z 1G3
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56
Kawartha Centre - Redefining Healthy Aging
Peterborough, Ontario, Canada, K9H 2P4
Actively Recruiting
57
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
58
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
59
Genge Partners Inc.
Montreal, Quebec, Canada, H4A 3T2
Actively Recruiting
60
Aalborg Universitetshospital
Aalborg, Denmark, 9000
Actively Recruiting
61
Aarhus Universitetshospital Skejby
Aarhus N, Denmark, 8200
Actively Recruiting
62
Rigshospitalet, Hukommelsesklinikken
København Ø, Denmark, 2100
Actively Recruiting
63
CHU Amiens Hopital Sud
Amiens Cedex1, France, 80054
Actively Recruiting
64
Centre Hospitalier Universitaire de Bordeaux Hopital Pellegrin
Bordeaux, France, 33076
Actively Recruiting
65
Groupement Hospitalier Est - Hôpital Neurologique
Bron, France, 69677
Actively Recruiting
66
CHU Dupruytren - Limoges
Limoges, France, 87042
Actively Recruiting
67
Hopital Gui de Chauliac
Montpellier, France, 34295
Actively Recruiting
68
Ch Pitie Salpetriere
Paris, France, 75651
Actively Recruiting
69
CHU de Rouen Hopital
Rouen, France, 76031
Actively Recruiting
70
Hop Guillaume Et Rene Laennec
Saint-Herblain, France, 44800
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71
Hôpital Robertsau
Strasbourg, France, 67000
Actively Recruiting
72
Universitaetsklinikum Erlangen
Erlangen, Bavaria, Germany, 91054
Actively Recruiting
73
Ambulates Gesundheitszentrum der Charité GmbH
Berlin, Germany, 12200
Actively Recruiting
74
ECRC Experimental and Clinical Research Center, Charité Campus Berlin Buch, Memory Clinic
Berlin, Germany, 13125
Actively Recruiting
75
German Center for Neurodegenerative Diseases (DZNE)
Bonn, Germany, 53127
Actively Recruiting
76
Universitätsklinikum Köln
Cologne, Germany, 50937
Actively Recruiting
77
Medizinische Fakultät Carl Gustav Carus
Dresden, Germany, 01307
Actively Recruiting
78
Universitätsklinikum des Saarlandes Klinik f. Psychiatrie und Psychotherapie
Homburg/Saar, Germany, 66421
Actively Recruiting
79
Universitätsklinikum Jena, Klinik für Neurologie
Jena, Germany, 07747
Actively Recruiting
80
Universität Leipzig
Leipzig, Germany, 04103
Actively Recruiting
81
Otto-von-Guericke-Universität Magdeburg
Magdeburg, Germany, 39120
Actively Recruiting
82
Zentralinstitut für Seelische Gesundheit Abt.Gerontopsychiatrie
Mannheim, Germany, 68159
Actively Recruiting
83
LMU Klinikum, Neurologische Klinik und Poliklinik
München, Germany, 81377
Actively Recruiting
84
Ludwig-Maximilians-Univ.
München, Germany, 81377
Actively Recruiting
85
Universitätsklinikum Münster
Münster, Germany, 48149
Actively Recruiting
86
Neuropraxis München Süd
Unterhaching, Germany, 82008
Actively Recruiting
87
A. O. U. Federico II
Naples, Campania, Italy, 80131
Actively Recruiting
88
Nuovo Ospedale Civile S. Agostino-Estense
Modena, Emilia-Romagna, Italy, 41126
Actively Recruiting
89
Policlinico Universitario Agostino Gemelli
Rome, Lazio, Italy, 00168
Actively Recruiting
90
Ospedale Isola Tiberina - Gemelli Isola
Rome, Lazio, Italy, 00186
Actively Recruiting
91
AO di Perugia - Ospedale S. Maria della Misericordia
Perugia, Umbria, Italy, 06156
Actively Recruiting
92
Brain Attack Center Ota Memorial Hospital
Hiroshima, Japan, 720-0825
Actively Recruiting
93
National Hospital Organization Hiroshima-Nishi Medical Center
Hiroshima, Japan, 739-0696
Actively Recruiting
94
Kobe University Hospital
Hyōgo, Japan, 650-0017
Actively Recruiting
95
Kagawa University Hospital
Kagawa, Japan, 761-0793
Actively Recruiting
96
Kochi Medical School Hospital
Kochi, Japan, 783-8505
Actively Recruiting
97
Okayama City Hospital
Okayama, Japan, 700-8557
Actively Recruiting
98
Rijikai Medical Corporation Katayama Medical Clinic
Okayama, Japan, 710-0813
Actively Recruiting
99
Kotobuki Social Medical Corporation Tominaga Clinic
Osaka, Japan, 556-0015
Actively Recruiting
100
The University of Tokyo Hospital
Tokyo, Japan, 113-8655
Actively Recruiting
101
Higashi-Shinjuku Clinic
Tokyo, Japan, 169-0072
Actively Recruiting
102
Brain Research Center Den Bosch
's-Hertogenbosch, Netherlands, 5223 LA
Actively Recruiting
103
Brain Research Center B.V
Amsterdam, Netherlands, 1081 GN
Actively Recruiting
104
Brain Research Center Zwolle
Zwolle, Netherlands, 8025AZ
Actively Recruiting
105
O?rodek Badawczo-Naukowo-Dydaktyczny Chorób Ot?piennych w ?cinawie
?cinawa, Poland, 59-330
Actively Recruiting
106
ProNeuro Centrum Medyczne
?ory, Poland, 44-240
Actively Recruiting
107
Uniwersytet Medyczny w Lodzi
?ód?, Poland, 92-216
Actively Recruiting
108
Syberka-ClinHouse Sp. z o.o.
B?dzin, Poland, 42-500
Actively Recruiting
109
Podlaskie Centrum Psychogeriatrii
Bia?ystok, Poland, 15-756
Actively Recruiting
110
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland, 80-214
Actively Recruiting
111
Szpital Uniwersytecki w Krakowie
Krakow, Poland, 30-688
Actively Recruiting
112
Clinical Research Center Sp. z o.o. MEDIC-R Spó?ka Komandytowa
Późna, Poland, 61-731
Actively Recruiting
113
Centrum Medyczne "MEDYK"
Rzeszów, Poland, 35-326
Actively Recruiting
114
Senior Sp. Z O.O. Poradnia Psychogeriatryczna
Sopot, Poland, 81-855
Actively Recruiting
115
NeuroProtect
Warsaw, Poland, 01-684
Actively Recruiting
116
Pusan National University Hospital
Busan, South Korea, 602-739
Actively Recruiting
117
Chonnam National University Hospital
Gwangju, South Korea, 61469
Actively Recruiting
118
Ajou University Medical Center
Gyeonggi-do, South Korea, 16499
Actively Recruiting
119
St. Vincent's Hospital
Gyeonggi-do, South Korea, 442-723
Actively Recruiting
120
Gachon University Gil Medical Center
Incheon, South Korea, 21565
Actively Recruiting
121
Inha University Hospital
Incheon, South Korea, 22332
Actively Recruiting
122
Seoul National University Bundang Hospital
Seongnam-si, South Korea, 463-707
Actively Recruiting
123
Hanyang University Seoul Hospital
Seoul, South Korea, 04763
Actively Recruiting
124
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
125
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
126
Ewha Womans University Hospital (Seoul)
Seoul, South Korea, 07804
Actively Recruiting
127
Korea University Guro Hospital
Seoul, South Korea, 08308
Actively Recruiting
128
Hospital Universitario Marques de Valdecilla
Santander, Cantabria, Spain, 39011
Actively Recruiting
129
Fundación ACE
Barcelona, Spain, 08028
Actively Recruiting
130
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain, 08041
Actively Recruiting
131
Hospital Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
132
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
133
Hospital Victoria Eugenia
Seville, Spain, 41009
Actively Recruiting
134
Hospital Virgen del Rocío
Seville, Spain, 41013
Actively Recruiting
135
Hospital Universitario la Fe
Valencia, Spain, 46026
Actively Recruiting
136
Inselspital Bern Medizin Neurologie
Bern, Switzerland, 3010
Actively Recruiting
137
Hôpitaux universitaires de Genève
Geneva, Switzerland, 1211
Actively Recruiting
138
CHUV Lausanne Méd.Neurologie
Lausanne, Switzerland, 1011
Actively Recruiting
139
Ospedale Regionale di Lugano - Civico
Lugano, Switzerland, 6903
Actively Recruiting
140
ReMind UK
Bath, United Kingdom, BA1 3NG
Actively Recruiting
141
Re:Cognition Health Birmingham
Birmingham, United Kingdom, B16 8QQ
Actively Recruiting
142
Scottish Brain Sciences
Edinburgh, United Kingdom, EH12 9DQ
Actively Recruiting
143
Queen Elizabeth University Hospital Glasgow
Glasgow, United Kingdom, G51 4TF
Actively Recruiting
144
St George?s Hospital
London, United Kingdom, SW17 ORE
Actively Recruiting
145
RE:Cognition Health
London, United Kingdom, W1G 8TA
Actively Recruiting
146
UCL Institute of Neurology
London, United Kingdom, WC1N 3BG
Actively Recruiting
147
Manchester Mental Health and Social Care Trust
Manchester, United Kingdom, M13 9WL
Actively Recruiting
148
Warneford Hospital
Oxford, United Kingdom, OX3 7JX
Actively Recruiting
149
Lancashire and South Cumbria NHS Foundation Trust
Preston, United Kingdom, PR2 8DW
Actively Recruiting
150
Southampton University Hospitals NHS Trust
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
Research Team
R
Reference Study ID Number: WN45447 https://forpatients.roche.com/
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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