Actively Recruiting
Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia
Led by Medical College of Wisconsin · Updated on 2026-02-17
60
Participants Needed
25
Research Sites
194 weeks
Total Duration
On this page
Sponsors
M
Medical College of Wisconsin
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
BMT CTN 2207 will investigate the use of marrow transplantation for treatment of severe aplastic anemia that has not previously been treated.
CONDITIONS
Official Title
Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 3 and 75 years
- Confirmed diagnosis of acquired severe aplastic anemia with low bone marrow cellularity and low blood counts
- No suitable fully matched related donor available
- Available donor as defined by the study protocol
- Participant or legal guardian has signed informed consent
- Adequate organ function including heart, liver, kidney, and lung meeting specified criteria
- Karnofsky or Lansky performance status of 60% or higher
- Females and males of childbearing potential agree to use two effective contraception methods or abstinence
You will not qualify if you...
- Inherited bone marrow failure syndromes such as Fanconi anemia and short telomere syndromes
- Clonal cytogenetic abnormalities indicating pre-MDS or MDS
- Formal diagnosis of myelodysplastic syndrome
- Presence of donor-specific HLA antibodies above threshold
- Prior desensitization attempts for donor HLA antibodies
- Prior treatment for severe aplastic anemia such as immunosuppressive therapy or stem cell transplant
- Prior solid organ transplant
- Known life-threatening reaction to Thymoglobulin4
- Uncontrolled bacterial, viral, or fungal infections
- Pregnant or breastfeeding females
- Prior malignancies within 5 years except certain treated cancers
- HIV with detectable viral load or recent AIDS complications
- Uncontrolled hepatitis B or C infections not meeting criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
City of Hope
Duarte, California, United States, 91010
Actively Recruiting
3
University of California, Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
4
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
5
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
6
Emory Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
7
Blood and Marrow Transplant Center at Northside Hospital
Atlanta, Georgia, United States, 30342
Actively Recruiting
8
University of Kansas Medical Center
Westwood, Kansas, United States, 66205
Actively Recruiting
9
Johns Hopkins University
Baltimore, Maryland, United States, 21218
Actively Recruiting
10
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
11
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
12
Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Actively Recruiting
13
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
14
Washington University School of Medicine, Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
15
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10021
Actively Recruiting
16
UNC Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
17
Levine Cancer Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
18
Duke University Health System
Durham, North Carolina, United States, 27705
Actively Recruiting
19
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
20
University of Oklahoma
Oklahoma City, Oklahoma, United States, 73117
Actively Recruiting
21
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
22
Vanderbilt University
Nashville, Tennessee, United States, 37235
Actively Recruiting
23
Huntsman Cancer Institute
Salt Lake City, Utah, United States, 84112
Actively Recruiting
24
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Actively Recruiting
25
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
J
Jennifer Romeril
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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