Actively Recruiting
Clinical and Urodynamic Assessment of Bladder Sensation in Multiple Sclerosis
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-03-05
113
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the relationship between how bladder sensations change during filling and the severity of Overactive Bladder (OAB) symptoms in patients with multiple sclerosis (MS). Lower urinary tract symptoms are common in MS, with OAB being the most frequent complaint. This study focuses on bladder sensation progression as a potential factor influencing urinary symptoms in MS patients. Participants will undergo repeated cystometry procedures to assess bladder sensations. The study includes a second cystometry to check the reliability of bladder sensation measurements and a third cystometry combined with a cognitive task (STROOP test) to evaluate how attention affects bladder sensations. These procedures aim to better understand bladder function and sensation changes in MS. During the study, participants will have bladder sensations measured, focusing on the area under the sensation-capacity curve as the primary outcome. Secondary outcomes include bladder sensitivity. The study involves detailed urodynamic testing and assessments to monitor bladder function and sensations, helping to clarify mechanisms behind bladder disorders in MS. The study runs until February 2027, and participants will be carefully evaluated throughout.
CONDITIONS
Brief Title
Clinical and Urodynamic Assessment of Bladder Sensation in Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of multiple sclerosis according to 2017 Mac Donald criteria
- Presence of bladder disorders likely related to multiple sclerosis
- Indication to perform urodynamics
- Not currently taking medication for bladder disorders
- Ability to understand and write in French
- Affiliation to "Securite sociale", "Couverture Medicale Universelle (CMU)", or equivalent
You will not qualify if you...
- Under legal protection
- Pregnant or breastfeeding
- Multiple sclerosis relapse within the past month
- Other neurological diseases
- Genuine stress incontinence related to postpartum
- Treatment with antimuscarinics, alpha blockers, beta3 adrenergic agents, or tibial nerve stimulation within the past 15 days
- Botulinic toxin injection within the past 6 months
- Previous lower urinary tract surgery
- Inability to use the analogic device due to motor, sensory, or ataxic disabilities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo repeated cystometries to assess bladder sensations and the impact of cognitive tasks on these sensations.
3 visits (in-person)
Trial Site Locations
Total: 1 location
1
Hôpital TENON
Paris, Choisir Une Région, France, 75020
Actively Recruiting
Research Team
C
Claire Hentzen, MD
G
Gérard AMARENCO, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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