Actively Recruiting
CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLL
Led by Technical University of Munich · Updated on 2026-03-23
50
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate whether a short-term (4-week) whole-food, plant-based (WFPB) diet has an effect on metabolism, immune function, and disease activity in early-stage chronic lymphocytic leukemia (CLL). The main questions the study aims to answer are: * Does a WFPB diet influence disease progression? * How do CLL cells and other immune cell types respond to a WFPB diet in terms of metabolism and signaling? Researchers will examine whether a WFPB diet can affect absolute lymphocyte counts in participants' blood and what metabolic or functional changes occur within the CLL cells. Participants will: * Switch to a WFPB diet for 4 weeks following an introductory session with a certified dietary instructor. * Visit the clinic before starting the diet and again after 14 and 28 days for blood draws and to provide stool samples. * Keep a diary of all foods and drinks consumed during the week prior to and throughout the study period.
CONDITIONS
Official Title
CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed chronic lymphocytic leukemia (CLL) diagnosis
- No previous treatments, currently managed with watch and wait
- Willing to follow a whole-food, plant-based diet for 4 weeks
- Willing to participate in 3 blood draws during the study
You will not qualify if you...
- Need for emergency interventions
- Already following a whole-food, plant-based or vegan diet
- CLL progression requiring treatment
- Insulin-dependent diabetes
- Taking lipid-lowering medications such as statins
- Body mass index (BMI) less than 20
- Any safety concerns as judged by the investigator regarding ability to complete the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Klinikum der Technischen Universität München (Klinikum rechts der Isar)
München, Bavaria, Germany, 81676
Actively Recruiting
Research Team
M
Maike Buchner-Mayr, PD Dr.
CONTACT
A
Anna Herr, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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