Actively Recruiting
Clonal Evolution in Follicular Lymphoma
Led by National Cancer Institute (NCI) · Updated on 2026-04-29
200
Participants Needed
1
Research Sites
596 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Follicular lymphoma is a type of cancer of the lymph nodes. Lab studies are important for cancer research. They help scientists better understand differences in the cancer biology of different patients. Researchers want to collect serial samples over time from people with follicular lymphoma to help them design future treatments. Objective: To collect a variety of samples from people with follicular lymphoma to study how these diseases progress and respond to treatment. Eligibility: Adults at least 18 years old who have been diagnosed with, but have not yet had any treatment for, follicular lymphoma. Design: Participants will be screened with medical history and physical exam. They will answer questions about daily functioning. They will have blood and urine tests. They may have scans and have tissue samples taken. Participants will be monitored about every 4 months for up to 2 years. They will repeat screening tests. They will have a cheek swab. A small brush will be rubbed against the inside of the cheek to wipe off some cells. Participants will have imaging scans about every 8 months for up to 2 years. Participants may have a bone marrow aspiration and biopsy. The hipbone will be numbed with a small needle. A needle will be put into the hipbone, and about 2 tablespoons of bone marrow will be taken out through the needle. Participants will continue being monitored every 6 months for up to 5 years, then 1 time a year.
CONDITIONS
Official Title
Clonal Evolution in Follicular Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed follicular lymphoma (grades 1-2 or 3a) confirmed by the Laboratory of Pathology, NCI
- Measurable or evaluable disease on CT or FDG-PET scans
- Age 18 years or older
- ECOG performance status less than 2 (Karnofsky score above 60%)
- Adequate tissue available from original diagnostic biopsy or optional repeat biopsy if needed
You will not qualify if you...
- Previous history of diffuse large B-cell lymphoma or histologic transformation
- Any prior systemic treatment for lymphoma including chemotherapy, biologic, or monoclonal antibody therapy (radiotherapy permitted)
- Patients who have received systemic therapy for other malignancies unless it ended at least 3 years prior and no active malignancy exists other than follicular lymphoma
- HIV-positive status
- Any second cancer requiring active systemic therapy
- Any other life-threatening non-lymphoma disease
- Inability to provide informed consent
- Pregnancy or breastfeeding
AI-Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
N
NCI Medical Oncology Referral Office
CONTACT
R
Rahul Lakhotia, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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