Actively Recruiting
Clonal Hematopoiesis of Indeterminate Potential in Heart Failure.
Led by FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS · Updated on 2025-05-30
300
Participants Needed
2
Research Sites
146 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is part of the Rico Macro-Project, a multidisciplinary research program promoted by FROM in collaboration with the ASST-PG23 and ATS Bergamo, aiming to investigate the role of clonal hematopoiesis on inflammation, studying in depth the mechanisms underlying the inflammatory process to determine their correlation with some important pathologies in different clinical fields (Hematology, Cardiology, Neurology, Pneumology, Gastroenterology, and Diabetology, etc.). In this context, the prospective observational study RICO-HF is developed. The RICO HF is the first project focused on CHIP and inflammation in the area of Cardiology, specifically in HF.
CONDITIONS
Official Title
Clonal Hematopoiesis of Indeterminate Potential in Heart Failure.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Consecutive patients admitted to the Cardiology Unit of the ASST Papa Giovanni XXIII Hospital, Bergamo for acute heart failure or attending the outpatient heart failure clinic for chronic heart failure
- Age over 18 years
- Written informed consent
You will not qualify if you...
- Chronic therapy with anti-inflammatories, steroids, immunomodulators, immunosuppressants, or chemotherapeutic agents
- Previous heart transplant
- Cardiogenic shock or cardiac arrest
- Recent acute coronary syndrome (less than 3 months)
- Current acute infection requiring specific treatment
- Overt myeloproliferative neoplasms (MPNs)
- Primary myelodysplastic syndromes
- Malignant cancers
- Non-cardiovascular co-morbidity reducing life expectancy to less than 1 year
- Any factor precluding 1-year follow-up
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
ATS BERGAMO Agenzia di Tutela della Salute
Bergamo, Italy, 24121
Active, Not Recruiting
2
Asst Papa Giovanni Xxiii - Dip. Di Cardiologia
Bergamo, Italy, 24127
Actively Recruiting
Research Team
A
Antonello Gavazzi, MD
CONTACT
F
FENILI
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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