Study of Clonal Hematopoiesis and Inflammation in Blood and Vessels The CHIVE Registry and Biorepository for Patients with Clonal Hematopoiesis or Risk Factors

What this Trial Is About

Researchers are investigating the relationship between clonal hematopoiesis CH and various health conditions, focusing on its link to increased risks of certain cancers and heart disease. This observational study aims to better understand clinical outcomes, cardiovascular features, and the risk of blood cancers in patients with CH or those at higher risk for CH. The study also seeks to create a biorepository of patient samples to support further research on CHs natural history. Participants will be involved in the CHIVE Registry and Biorepository, where they will provide blood and saliva samples, and if already undergoing the procedure, bone marrow samples as well. The study will follow participants for up to approximately 120 months to collect data and samples that help characterize the clinical impact of CH and related conditions. During the study, participants will undergo sample collections and provide informed consent. Researchers will evaluate the development and prognosis of hematologic malignancies and cardiovascular risk factors associated with CH. The long-term follow-up allows for ongoing assessment of health outcomes related to CH mutations, supporting a deeper understanding of its effects over time.

The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepository