The effects of clonidine on postoperative analgesia after peripheral nerve blockade in children.
Giovanni Cucchiaro, Arjunan Ganesh
https://pubmed.ncbi.nlm.nih.gov/17312203/Actively Recruiting
Led by Universidade Federal do Rio de Janeiro · Updated on 2025-07-14
62
Participants Needed
1
Research Sites
19 weeks
Total Duration
Researchers are evaluating the use of an ultrasound-guided nerve block technique called rectus sheath block RSB as the only anesthetic method for adults undergoing outpatient umbilical hernia surgery. The study compares two groups one receiving RSB with an added medication called clonidine, and the other receiving RSB without clonidine. The goal is to see if clonidine improves pain control, reduces the need for additional pain medications, and supports better recovery without adding risks. Participants will receive bilateral RSB performed with real-time ultrasound guidance using a specific needle and monitored sedation as needed. The intervention group receives a local anesthetic solution with clonidine, while the control group receives the same anesthetic without clonidine. Both solutions include lidocaine and ropivacaine diluted in saline and administered on each side. The study is randomized, double-blind, and controlled, with careful data management and safety monitoring during surgery. During the first 48 hours after surgery, participants will answer questionnaires assessing pain intensity, recovery quality, and sedation levels. Pain is measured at the recovery unit, 24 hours, and 48 hours post-surgery. Researchers will also track opioid use during and after surgery, as well as any side effects like nausea or vomiting. The study aims to provide important information about improving anesthesia techniques for safer and more comfortable hernia repair.
CONDITIONS
Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty
S
Samuel N Abreu, MD
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Universidade Federal do Rio de Janeiro
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants receive bilateral ultrasound-guided rectus sheath block (RSB) with or without clonidine before undergoing outpatient umbilical hernioplasty under sedation and standard monitoring.
1 preoperative visit (in-person) on surgery day
Duration - 48 hours postoperative
Participants are assessed for postoperative pain, opioid consumption, recovery quality, and adverse events for 48 hours after surgery.
3 visits: at post-anesthesia care unit admission, 24 hours, and 48 hours after surgery
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Giovanni Cucchiaro, Arjunan Ganesh
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https://pubmed.ncbi.nlm.nih.gov/33752119/Universidade Federal do Rio de Janeiro
Lead Sponsor