Effectiveness of Closed-Blood Sampling Devices in Adult Critically Ill Patients: Multicenter Randomized Clinical Trial

What this Trial Is About

This research aims to evaluate the use of Closed-Blood Sampling Devices (CBSD) compared to the usual practice of blood collection with waste discard volume in critically ill adult patients who have an arterial catheter. The study focuses on measuring the number of red blood cell transfusions and arterial catheter-related adverse events during the patients' stay in the Intensive Care Unit (ICU), up to a maximum of 21 days. It is a randomized, double-blind clinical trial led by the University of Barcelona. Patients who have had an arterial catheter for 24 hours and are expected to have it for at least 72 more hours may be included. Those randomized to the CBSD group will have the device placed on their arterial line and all blood samples drawn through it, eliminating discard volume. The control group will have blood collected using the usual open system, which requires discarding some blood. Blood loss volume and laboratory tube counts will be recorded daily for up to 21 days or until ICU discharge or death. Catheter insertion and maintenance procedures are the same for both groups. Participants will be monitored daily for blood analysis results, blood transfusions, and any adverse events related to the arterial catheter. After ICU discharge, patients will be followed for 48 hours to check if they received red blood cell transfusions and their hemoglobin and hematocrit levels. The study measures the units of red blood cells transfused, blood volume drawn, hemoglobin and hematocrit levels, and adverse events during the ICU stay and up to 21 days after randomization.

Closed-blood Sampling Devices in the Adult Critically Ill Patient