Actively Recruiting
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
Led by Fisher and Paykel Healthcare · Updated on 2026-05-05
70
Participants Needed
3
Research Sites
94 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients' SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with hypoxemia/respiratory distress.
CONDITIONS
Official Title
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has cognitive ability to provide informed consent
- Aged 22 years or older
- Hospitalized with hypoxemia/respiratory distress
- Diagnosis of COPD
- Candidate for or currently prescribed nasal high flow oxygen therapy with flow rate of at least 25 L/min
- Expected duration of oxygen and nasal high flow therapy greater than 24 hours (not necessarily continuous)
You will not qualify if you...
- Receiving Non Invasive Ventilation (NIV) or indicated for NIV per guidelines
- Hemodynamic instability (systolic blood pressure less than 90 mmHg or need for vasopressor/inotropic support)
- Receiving end of life care
- Nasal or facial conditions preventing use of nasal high flow
- Pregnancy or breastfeeding
- Cognitive impairment or impaired consciousness preventing informed consent
- Unsuitable for adhesive finger pulse oximetry
- Any condition deemed a safety risk by the investigator
- Active comorbidities expected to significantly affect condition within 30 days
- Prior participation in this clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Central Iowa Hospital Corp - UnityPoint Health
Des Moines, Iowa, United States, 50309
Actively Recruiting
2
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
3
Temple University Hospital
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
Research Team
J
Jenny Han
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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