Actively Recruiting
CML Pediatric ITK Response According to Molecular Identification at Diagnosis
Led by University Hospital, Bordeaux · Updated on 2024-08-14
88
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Treatment of chronic myeloid leukemia (CML) has been revolutionized by tyrosine kinase inhibitor (TKI). Nevertheless, case of failure and suboptimal response are still observed even in children. Pediatric CML is a rare disease and differs from adult in terms of disease presentation and treatment response underlying a likely different CML biology. Molecular mechanisms that induce resistance to TKI are still poorly characterized except mutations in the tyrosine kinase domain of BCR::ABL1. We propose to search for a molecular signature to predict the response to TKI in the pediatric population.
CONDITIONS
Official Title
CML Pediatric ITK Response According to Molecular Identification at Diagnosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at diagnosis less than or equal to 18 years
- Presence of a Philadelphia chromosome detected by cytogenetic analysis (conventional karyotype or Fluorescence In Situ Hybridization (FISH)) and a BCR ::ABL1 transcript e13a2 ou e14a2
- Diagnosis in chronic phase according to the European Leukemia Net (ELN) criteria
- First-line treatment with TKIs
- Possible pre-treatment with hydroxyurea
- DNA available at diagnosis
- RNA available for a sub-group patients (8 responders vs 8 no responders)
You will not qualify if you...
- Age at diagnosis more than 18 years
- Diagnosis in accelerated phase or blastic phase
- First line treatment other than TKI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU de Bordeaux, Service Hématologie Biologique
Bordeaux, France
Actively Recruiting
Research Team
S
Stéphanie DULUCQ
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here