Actively Recruiting
CMR-Based Prognostic Study in Patients With Cardiac Implantable Electronic Devices
Led by Chinese Academy of Medical Sciences, Fuwai Hospital · Updated on 2026-01-27
1500
Participants Needed
1
Research Sites
1617 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cardiac implantable electronic devices (CIEDs) are widely used to treat patients with heart failure, malignant arrhythmias, and other conditions. However, accurately identifying suitable candidates for CIED implantation remains a clinical challenge. Cardiovascular magnetic resonance imaging (CMR) provides a comprehensive assessment of cardiac structure, function, and tissue characteristics, facilitating evaluation of the myocardial substrate for arrhythmias. This study aims to evaluate the prognostic value of multiparametric CMR-derived imaging markers in CIED patients through preoperative CMR examinations. Imaging parameters of interest include structural-functional indices, myocardial strain, late gadolinium enhancement, entropy, and T1 and T2 mapping. Long-term clinical outcomes will be obtained from existing medical records and follow-up. The primary endpoint is sudden cardiac death (SCD) or SCD-equivalent events, defined as SCD, resuscitated cardiac arrest, sustained ventricular tachycardia or ventricular fibrillation, or appropriate ICD therapy. Secondary endpoints include all-cause mortality or heart failure rehospitalization. This study aims to elucidate the role of CMR in assessing CIED treatment indications and long-term risk stratification, thereby helping to optimize CIED implantation decisions.
CONDITIONS
Official Title
CMR-Based Prognostic Study in Patients With Cardiac Implantable Electronic Devices
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥18 years old)
- Patients with guideline-based reasons for cardiac implantable electronic device therapy, including pacemaker, implantable cardioverter-defibrillator, or cardiac resynchronization therapy
- Patients who had cardiovascular magnetic resonance imaging as part of routine clinical evaluation before CIED implantation or consideration
You will not qualify if you...
- Patients under 18 years old
- Patients with non-diagnostic or poor-quality CMR images preventing reliable analysis
- Patients with incomplete key clinical data or missing follow-up for primary outcome
- Patients with prior heart transplantation or ventricular assist device implantation before CMR
- Patients with congenital heart disease requiring surgical correction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing, China
Actively Recruiting
Research Team
X
Xinqiao Lian
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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