Actively Recruiting
CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
Led by University of Texas at Austin · Updated on 2026-02-19
600
Participants Needed
2
Research Sites
225 weeks
Total Duration
On this page
Sponsors
U
University of Texas at Austin
Lead Sponsor
B
Boston University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question "can this easy-to-administer assay aid clinicians in deciding whether or not to initiate exposure-based therapy?"
CONDITIONS
Official Title
CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 70 years
- A primary DSM-5 diagnosis of panic disorder (with or without agoraphobia), social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, or post-traumatic stress disorder confirmed by SCID-5
- Overall Anxiety Severity and Impairment Scale (OASIS) score of 8 or higher
- Willingness and ability to provide informed consent and follow the study protocol
- Proficiency in English, as assessments are validated only in English
You will not qualify if you...
- History of bipolar or psychotic disorders, substance use disorders (except nicotine), or eating disorder in the past 6 months
- Active suicidal thoughts with intent or recent suicidal behaviors within the past 6 months
- Medical conditions that prevent safe CO2 inhalation or hyperventilation challenge (such as cardiac arrhythmia, cardiac failure, asthma, lung fibrosis, high blood pressure, epilepsy, or stroke)
- Pregnancy or breastfeeding
- Currently undergoing psychotherapy for the primary disorder
- Started pharmacological treatment within 8 weeks before screening unless medication is stable
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Boston University
Boston, Massachusetts, United States, 02215
Actively Recruiting
2
The University of Texas at Austin
Austin, Texas, United States, 78712
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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