Actively Recruiting
Coconut Oil to Prevent Mouth Sores in Pediatric Patients Receiving High Dose Chemotherapy
Led by Wake Forest University Health Sciences · Updated on 2026-01-07
60
Participants Needed
1
Research Sites
697 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn if virgin coconut oil (VCO) mouth rinse can help prevent oral mucositis. The Study Investigator will compare standard of care mucositis prevention rinses with the VCO mouth rinse added to the standard of care mucositis prevention rinses. The severity of oral mucositis between the 2 groups will be evaluated. Some of the standard of care rinses that can be used to prevent mucositis are normal saline, Benadryl (diphenhydramine), Mylanta, lidocaine, or other combinations.
CONDITIONS
Official Title
Coconut Oil to Prevent Mouth Sores in Pediatric Patients Receiving High Dose Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent and HIPAA authorization obtained from participant or guardian
- Age between 7 and 26 years at time of consent
- Planned myeloablative conditioning regimen before hematopoietic stem cell transplant (HSCT)
- ECOG Performance Status C= 2 or Lansky/Karnofsky Performance Status E= 50 within 7 days before enrollment
- No mouth lesions at enrollment
- Ability of participant and caregiver to understand and follow study procedures
- Able and willing to swish and spit the oral rinse
You will not qualify if you...
- Allergy to tree nuts
- Planned discharge home before engraftment
- Use of coconut oil mouth rinses within 30 days before enrollment
- Use of other mouthcare regimens not allowed by institutional standards prior to admission
- Received HSCT within 90 days before admission
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Atrium Health Levine Children's Hospital
Charlotte, North Carolina, United States, 28203
Actively Recruiting
Research Team
S
Sceria Jenkins, RN
CONTACT
M
Marithza Amaya
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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