Actively Recruiting
Cognition, Flavonoids, Exercise, Gut Microbiome
Led by Appalachian State University ยท Updated on 2025-03-12
240
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.
CONDITIONS
Official Title
Cognition, Flavonoids, Exercise, Gut Microbiome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Score on the Montreal Cognitive Assessment (MoCA) between 24.1 and 25.2 indicating mild cognitive decline
- Healthy, non-smoking male or female aged 65 to 85 years
- Able to participate in a supervised 12-week exercise program (brisk walking or stretching)
- Physically inactive (less than 150 minutes moderate or 75 minutes vigorous exercise per week in past 4 weeks)
- Willing to be randomized into one of four study groups
- Agree to provide blood, urine, and fecal samples
- Willing to avoid eating blueberries outside of the study during the 12-week period
- Willing to maintain current diet and physical activity levels during the study
- Agree to participate only in this study and not join other studies concurrently
You will not qualify if you...
- Allergy to blueberries
- Diagnosis of Type I or Type 2 diabetes
- Uncontrolled chronic cardiovascular, metabolic, or kidney conditions (must be stable for at least 6 months)
- History of chest discomfort, dizziness, fainting, or blackouts during rest or exercise
- Use of prescription or over-the-counter drugs to support cognition or with cognitive side effects
- Any condition or medication use judged by the study clinician to prevent participation
- Diagnosis of dementia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Appalachian State University Human Performance Lab, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28081
Actively Recruiting
Research Team
D
David C Nieman, DrPH
CONTACT
C
Camila A Olson, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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