Study of Blueberry Intake and Exercise Effects on Mild Cognitive Decline in Older Adults Evaluating Gut Microbiome and Cognitive Function Over 12 Weeks

What this Trial Is About

Researchers are investigating the effects of daily blueberry intake combined with or without moderate exercise on cognitive function in older adults experiencing age-related cognitive changes. This clinical trial explores whether a diet rich in flavonoids and regular physical activity can improve cognition and reduce decline through changes in the gut microbiome. The study is randomized, double blind, and placebo controlled, focusing on healthy older adults aged 65 to 85 with mild cognitive decline. Participants will be randomly assigned to one of four groups for 12 weeks blueberry powder plus walking exercise, blueberry powder plus stretching exercise, placebo powder plus walking exercise, or placebo powder plus stretching exercise. The blueberry dose is 50 grams of freeze-dried powder daily, equivalent to two cups of fresh blueberries. Exercise sessions last 45 minutes each, five times per week, and are supervised. Both supplements and exercises are carefully monitored and designed to assess their combined or separate effects. Throughout the study, participants undergo multiple assessments including cognitive testing with the MoCA and CANTAB batteries, electrophysiological measures using a sensor net, and evaluations of aerobic fitness. Blood, urine, and stool samples are collected before the study begins and at 6 and 12 weeks to analyze gut microbiome changes and blueberry metabolites. Daily step counts are tracked via FitBit, and adherence to the supplement and exercise protocols is regularly checked. The main outcome is the change in cognitive function from baseline to 6 and 12 weeks.

Cognition, Flavonoids, Exercise, Gut Microbiome