Actively Recruiting
Cognition and Motor Learning Post-stroke
Led by University of Southern California · Updated on 2025-11-04
65
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
CONDITIONS
Official Title
Cognition and Motor Learning Post-stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Unilateral stroke
- Stroke occurred more than 6 months prior
- Paresis confined to one side
- Independently ambulatory (including the use of assistive devices)
- Able to walk for 5 minutes without stopping
- Answers no to all general health questions on the PAR-Q+
- Willingness to complete study procedures
You will not qualify if you...
- Brainstem or cerebellar stroke
- Aphasia (expressive, receptive, or global)
- Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
- Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
- Uncontrolled hypertension (>160/110mmHg)
- Concurrent physical therapy
- Claustrophobia
- Significant cognitive deficit or dementia (<20 on MoCA)
- Inability to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Center for Health Professions
Los Angeles, California, United States, 90033
Actively Recruiting
Research Team
K
Kristan Leech, PT, DPT, PhD
CONTACT
S
Sarah Kettlety, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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