What is this study trying to find out about thyroid nodules and cognitive function?

This study aims to understand how cognitive function changes in patients undergoing surgery for thyroid nodules, including different types of thyroid cancer. Researchers are examining objective cognitive tests, hormone levels, physical activity, and quality of life to see how these factors relate. The study is sponsored by Karolinska University Hospital.

Who may be eligible for this thyroid nodule clinical trial?

Adults aged 18 years and older with a thyroid nodule requiring surgery classified as Bethesda IV-VI may be eligible. Participants must understand Swedish, have internet access, and be able to consent. Those with autoimmune hypothyroidism or prior cancers (except basal cell skin cancer) are excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this thyroid nodule clinical trial?

Study-related care, including all tests and visits, is provided at no cost. However, personal expenses such as travel may not be covered. Participants should plan accordingly for any costs related to attending study visits.

Actively Recruiting

Age: 18Years +

All Genders

ID05088187

Longitudinal Evaluation of Cognitive Function and Quality of Life After Surgery for Malignant and Benign Thyroid Nodules

Led by Karolinska University Hospital · Updated on 2023-01-18

320

Participants Needed

Research Sites

156 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying cognitive function and quality of life in people who have surgery for thyroid nodules. The study aims to understand the extent of objective cognitive problems and how they relate to subjective cognitive complaints, thyroid hormone levels, physical activity, and health-related quality of life. This prospective study includes patients with benign thyroid nodules, low-risk differentiated thyroid cancer, and intermediate to high-risk thyroid cancer. Participants are divided into three groups those with follicular adenomas, those with very low-risk thyroid cancer, and those with low to high-risk thyroid cancer. The main comparison focuses on patients with follicular adenomas and those with higher-risk thyroid cancer. Cognitive function is assessed using an online neuropsychological test called the Amsterdam Cognition Scale ACS. Participants complete online cognitive tests and questionnaires about quality of life, physical activity, and other psychological and physical symptoms at multiple times from before surgery up to 12 months after surgery. Blood samples are taken to measure thyroid hormone levels and signs of inflammation. The study measures objective cognitive function over time to better understand its impact on survivors of thyroid conditions.

CONDITIONS

Brief Title

Cognition and QoL After Thyroid Surgery

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Age over 18 years
Indication for surgery due to a thyroid nodule classified as Bethesda IV-VI
Ability to read and understand the Swedish language
Access to a desktop computer or laptop with internet connection
Willingness and ability to provide written informed consent

You will not qualify if you...

Previous diagnosis of autoimmune hypothyroidism
Previous cancer diagnosis except basal cell skin cancer
Surgery indications other than solely a thyroid nodule (e.g., Graves disease)
Diagnosis of medullary or anaplastic thyroid cancer

Research Team

Renske Altena, MD PhD

Cia Ihre Lundgren, MD Ass Professor

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