Study of Cognitive Tests for Adults Aged 30 to 65 With Huntingtons Disease

What this Trial Is About

Researchers are exploring two cognitive tools, the Coding Test and the Self-Administered Gerocognitive Examination SAGE, which are not commonly used in Huntington Disease HD clinical trials. These tools have been applied in other neurodegenerative diseases like Alzheimers, Parkinsons, and Lewy Body Disease, but their usefulness in HD patients is not well understood. The study aims to expand knowledge about these tools for initial screening and clinical trial use in HD. Participants will attend a single visit lasting about 1 to 1.5 hours at the OSU Wexner Medical Center Huntington Society of America Center of Excellence Clinic. During this visit, vital signs such as weight, blood pressure, temperature, respiratory rate, and pulse will be measured. Medical records will be reviewed for demographics, medications, medical and surgical history, family history of HD, and diagnosis details. Participants will complete cognitive, functional, and motor assessments using a standardized battery. Throughout the visit, researchers will document any adverse events and perform assessments including the Symbol Digit Modality Test SDMT, Coding Test, Self-Administered Gerocognitive Examination SAGE, Luria test, and parts of the Unified Huntingtons Disease Rating Scale UHDRS. They will analyze correlations between various test scores and HD symptom onset age. The study focuses on evaluating cognitive tools in HD patients aged 30 to 65 who meet specific genetic and clinical diagnosis criteria.

Cognitive Assessment Tools for Huntington's Disease.