Actively Recruiting

Phase Not Applicable
Age: 40Years - 65Years
All Genders
Healthy Volunteers
NCT06338774

Cognitive Control to Boost Physical Activity Adherence

Led by University of Iowa · Updated on 2025-12-11

264

Participants Needed

2

Research Sites

169 weeks

Total Duration

On this page

Sponsors

U

University of Iowa

Lead Sponsor

N

Northeastern University

Collaborating Sponsor

AI-Summary

What this Trial Is About

This trial is designed to develop and test the efficacy of cognitive training strategies to improve self-regulatory capacities for middle-aged adults to adopt and sustain a physically active lifestyle. The main questions it aims to answer are: * Can cognitive training designed to improve cognitive control improve physical activity adherence? * What are the psychological, physiological, cognitive, and sociodemographic factors that affect the impact of cognitive control on physical activity adherence? Participants will * Complete a 6-week home-based, computerized cognitive training program * Complete a 6-week home-based, aerobic exercise training program with supervision of a health coach and trainer * Complete a 6-week home-based, aerobic exercise training program prescribed by a health coach and trainer * Visit the laboratory before and after cognitive training, and before and after physical training, to complete assessments of cognition and aerobic fitness

CONDITIONS

Official Title

Cognitive Control to Boost Physical Activity Adherence

Who Can Participate

Age: 40Years - 65Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Between the ages of 40 and 65 years old
  • Working full-time an average of 35 hours per week or more
  • Scoring as "Low Active" on the short form of the International Physical Activity Questionnaire
  • Eligible for aerobic exercise based on the Physical Activity Readiness Questionnaire
  • Approved by primary care physician to participate in the prescribed training program
  • Corrected vision of 20/40
  • Fluent in English to understand cognitive assessments and training instructions
Not Eligible

You will not qualify if you...

  • Hearing impairments that prevent understanding study instructions
  • Visual impairments preventing color perception or visual field loss
  • Classified as "high risk" for exercise-induced adverse events, including known or symptomatic chronic cardiovascular or metabolic diseases
  • Not fluent in English
  • Unable to follow study instructions or access a computer or tablet for training
  • Previous diagnosis of neurological or psychiatric conditions such as major depression, ADHD, schizophrenia, bipolar disorder, multiple sclerosis, epilepsy, meningitis, Parkinson's disease, stroke, TIA, or brain aneurysm surgery
  • Previous diagnosis of heart conditions, cardiovascular disease, or recent cardiovascular events that increase risk during vigorous exercise, chronic obstructive pulmonary disease, or uncontrolled asthma
  • Previous diagnosis of chronic conditions such as cystic fibrosis, unregulated thyroid disorder, untreated diabetes, renal or liver disease, heart murmur, arrhythmia, or irregular heartbeat
  • History of brain surgery or injury requiring rehabilitation or caregiver assistance
  • Previous diagnosis of Alzheimer's disease or related dementias
  • Current or recent cancer treatment within the last 6 months
  • Pregnant or trying to get pregnant

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 2 locations

1

Psychological and Brain Sciences Building

Iowa City, Iowa, United States, 52242

Actively Recruiting

2

Center for Cognitive and Brain Health

Boston, Massachusetts, United States, 02115

Actively Recruiting

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Research Team

M

Michelle W Voss, PhD

CONTACT

C

Charles Hillman, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

3

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