Actively Recruiting

Phase Not Applicable
Age: 8Years - 12Years
All Genders
NCT06102941

Cognitive Control Targets for the Treatment of Obsessive Compulsive Disorder in Young Children

Led by Columbia University · Updated on 2025-11-06

60

Participants Needed

1

Research Sites

109 weeks

Total Duration

On this page

Sponsors

C

Columbia University

Lead Sponsor

N

National Institute of Mental Health (NIMH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study aims to examine the effects of a game-like program called cognitive control training (CT) for children with obsessive compulsive disorder (OCD). Children enrolled in this study will receive 4 weeks of the at-home computerized cognitive training program (AKL-T01) delivered on iPad (25 minutes/day, 5 days/week). Styled as a child-friendly video game, AKL-T01 CT taps focused attention, response inhibition, and working memory using a series of games to engage cognitive control processes. Children will complete the NIH Toolbox prior to, mid (2-weeks), and post-CT (4-weeks). Participants will complete MRI scans pre- and post-CT and then be offered a 12-week course of gold-standard Cognitive behavioral therapy with exposure and response prevention (or community referrals) after CT. The long-term goal of this study is to test how this CT intervention may enhance cognitive control capacity to reduce symptoms and improve response to cognitive behavioral therapy with exposure and response prevention in children with OCD.

CONDITIONS

Official Title

Cognitive Control Targets for the Treatment of Obsessive Compulsive Disorder in Young Children

Who Can Participate

Age: 8Years - 12Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Ages between 8 and 12 years
  • Clinically significant OCD as the main problem, meeting DSM-V criteria assessed by K-SADS-PL
  • OCD causes primary interference and distress, with a Children’s Yale-Brown Obsessive Compulsive Scale (C-YBOCS) score of 16 or higher
  • Not currently on psychotropic medication or has been medication-free for at least three months
  • Not receiving current psychotherapy for OCD
  • Able to tolerate a treatment-free period except study CBT
  • Able to provide informed assent
Not Eligible

You will not qualify if you...

  • Current or past diagnosis of major depressive disorder, PTSD, substance/alcohol abuse, psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, substance/alcohol dependence, or other Axis I disorders not listed
  • Active suicidal thoughts
  • Females who are pregnant or nursing
  • Major medical or neurological problems such as unstable hypertension, seizure disorder, or head trauma
  • Positive urine screen for illicit drugs
  • Presence of metallic device or dental braces
  • IQ below 80

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Columbia University Irving Medical Center

New York, New York, United States, 10032

Actively Recruiting

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Research Team

M

Marsh Lab

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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