Actively Recruiting
Cognitive Decline in AD
Led by Chinese University of Hong Kong · Updated on 2024-08-21
500
Participants Needed
1
Research Sites
472 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is lack of information on the risk factors of accelerated cognitive decline in older people with Alzheimer disease (AD). The extent of neurodegeneration and white matter disease has been reported to be important factors. In addition there may be biomarkers e.g. inflammatory cytokines that can contribute to cognitive decline. The impact of care arrangement and physical activity may also be important. Insulin signaling is impaired in Alzheimer disease (AD). We therefore propose to perform a cohort study of older people with AD. This will be based on an on-going AD registry which was designed to identify genetic biomarkers for AD. Detailed neurocognitive tests and lifestyle information are available. In addition, volumetric MRI brain scans were performed in all AD subjects. The hypothesis is that MRI brain volumes, serum biomarkers, physical activity, physical functioning are independently associated with cognitive decline in older people with AD. The objective is to identify risk factors of accelerated cognitive decline so that preventive measures can be designed to delay dependency in AD.
CONDITIONS
Official Title
Cognitive Decline in AD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Sufficient Cantonese competency for cognitive test
- Clinical diagnosis of AD
- FAST test staging 3-5
- Age between 65 and 92 years
You will not qualify if you...
- Refusal to provide blood samples
- No reliable family caregiver informant who contacts at least once a month
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
T
Timothy Kwok, MD
CONTACT
H
Hazel Mok, BSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here