Actively Recruiting
Brain Imaging Study on Cognitive Changes After Deep Brain Stimulation Surgery in Parkinsons Disease
Led by Medical University of South Carolina · Updated on 2026-05-29
80
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating brain changes that may predict cognitive decline in people with Parkinsons Disease who undergo Deep Brain Stimulation DBS. This study focuses on understanding why some patients experience worsening thinking skills after DBS surgery despite careful evaluations before treatment. It aims to improve patient selection and stimulation targeting to reduce cognitive side effects. The study will include 55 Parkinsons Disease patients scheduled for DBS surgery and 25 healthy participants without Parkinsons for comparison. Participants will undergo pre-surgery MRI scans and cognitive assessments, followed by a one-year post-surgery cognitive evaluation for the DBS group. The DBS procedure itself is part of standard clinical care. Participants will attend four visits, including screening, MRI scanning, and cognitive testing sessions before and after surgery. Researchers will collect brain imaging data and monitor changes in cognition over one year. They will also assess brain structure and function using specific MRI techniques. This longitudinal monitoring aims to identify markers linked to cognitive changes following DBS.
CONDITIONS
Brief Title
Cognitive Decline Following Deep Brain Stimulation
Research Team
D
Daniel H Lench, PhD
G
Gonzalo J Revuelta, DO
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