Actively Recruiting
Cognitive Decline Following Deep Brain Stimulation
Led by Medical University of South Carolina · Updated on 2025-04-29
80
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.
CONDITIONS
Official Title
Cognitive Decline Following Deep Brain Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Planning to undergo deep brain stimulation surgery as part of clinical care for Parkinson's Disease
- Willing to have high-resolution MRI scans before surgery
- Agree to cognitive assessments before and one year after surgery
- For control participants: age 18 years or older and age matched to Parkinson's group
You will not qualify if you...
- Uncorrected visual or hearing impairments
- Pregnant or expecting to become pregnant during the study
- Claustrophobia or inability to lie flat in MRI scanner
- COPD requiring oxygen support
- Presence of metal implants not compatible with MRI (e.g., surgical clips, staples, pacemakers)
- Diagnosis of Parkinson's Disease or other movement disorders (for control participants)
- Untreated neuropsychiatric disorders (for control participants)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
D
Daniel H Lench, PhD
CONTACT
G
Gonzalo J Revuelta, DO
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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