Actively Recruiting
Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
Led by Medical University of South Carolina · Updated on 2025-10-14
55
Participants Needed
1
Research Sites
136 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with Parkinson's Disease (PD). A total of 55 participants with PD who have undergone DBS surgery will be recruited from MUSC's Clinical DBS Program. Participants will attend two post-DBS visits: a 3-hour visit for consent, demographic, and cognitive assessments, and a 3-hour DBS-MRI visit to evaluate brain network connectivity with stimulation ON and OFF. These findings will help improve patient selection for surgery and optimize the selection of stimulation targets that minimize undesirable cognitive side effects.
CONDITIONS
Official Title
Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects above 18 years of age
- Diagnosed with Parkinson's Disease as defined by UK Brain Bank diagnostic criteria
- Completed neurological and neuropsychological evaluation at MUSC's movement disorder center
- Selected to undergo 3T compatible unilateral or bilateral STN-DBS implants
You will not qualify if you...
- Uncorrected visual or hearing impairments
- Pregnant or expecting to become pregnant during the study
- History of neurological diseases other than Parkinson's Disease, including stroke, major head trauma, epilepsy, or seizures
- Claustrophobia or inability to lie supine in an MRI scanner
- COPD requiring oxygen
- Presence of non-MRI compatible metal implants such as surgical clips, staples, or cardiac pacemakers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
R
Recruitment Coordinator
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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