Actively Recruiting
Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia
Led by Massachusetts General Hospital · Updated on 2025-02-10
100
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
P
Platelet Disorder Support Association (PDSA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Individuals with immune thrombocytopenia (ITP) frequently report difficulties with attention and memory. The main question this study seeks to answer is: Do patients with ITP have evidence of cognitive impairment as detected by a cognitive function test battery? To address this issue, participants will take a cognitive function test and complete surveys on quality of life, fatigue, depression, and cognitive symptoms. The primary aim of the study is to evaluate for the presence and extent of cognitive impairment in patients with ITP. The study will also assess whether cognitive impairment in ITP is associated with patient-reported impacts on quality of life, fatigue, mood, and cognitive symptoms as well as clinical characteristics such as ITP disease and treatment history.
CONDITIONS
Official Title
Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 218 years or older
- Clinical diagnosis of persistent or chronic ITP with platelet counts <50 x 10^9/L on two occasions in the past 3 to 12 months or >12 months, respectively
- Documented response to at least one prior ITP-directed therapy such as corticosteroids, intravenous immune globulin, Rho(D) immune globulin, splenectomy, thrombopoietin receptor agonists, or fostamatinib
- Ability to follow instructions in English
You will not qualify if you...
- Pre-existing diagnosis of cognitive impairment due to dementia, stroke, or other neurological disease
- Active psychiatric disorder including uncontrolled major depression, schizophrenia, severe anxiety, or active alcohol or drug abuse
- Active cancer requiring or expected to require chemotherapy or surgery, except non-melanoma skin cancer
- Brain tumor or cranial surgery within the past year
- Significant hearing or vision impairment preventing completion of neurocognitive testing via a virtual platform
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
D
Debbie Jiang, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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