Actively Recruiting

Age: 14Years - 65Years
All Genders
Healthy Volunteers
ID07478510

Neuro-cognitive Profiles of Patients With Nutritional and Eating Disorders

Led by Istituti Clinici Scientifici Maugeri SpA · Updated on 2026-04-16

84

Participants Needed

3

Research Sites

N/A

Total Duration

On this page

Sponsors

I

Istituti Clinici Scientifici Maugeri SpA

Lead Sponsor

I

Istituto Psicologico Italiano s.r.l.s.

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to better understand the psychological and cognitive characteristics of Feeding and Eating Disorders (FEDs), focusing especially on Avoidant/Restrictive Food Intake Disorder (ARFID). ARFID is a condition marked by severe food avoidance not related to weight or shape concerns, but rather sensory sensitivities, fear of eating, or lack of interest in food. The study explores cognitive flexibility, autistic traits, body representation, and inhibitory control to clarify differences and similarities among ARFID and other eating disorders like anorexia nervosa and bulimia nervosa. Participants include adults aged 14 to 65 of all genders, with diagnoses of ARFID, anorexia nervosa, bulimia nervosa, or no history of eating disorders (healthy controls). Each participant completes several behavioral and computer-based tasks such as the Go/No-go task assessing response to food stimuli, the Implicit Association Test (IAT) measuring automatic attitudes towards body images, and the Wisconsin Card Sorting Test (WCST) evaluating cognitive flexibility. Each participant undergoes all assessments, with specific randomization in how tasks are administered. During the study, participants complete self-report questionnaires on autistic traits, body image, and psychological well-being. They perform tasks designed to measure cognitive flexibility, decision-making, inhibitory control, and automatic food-related associations. Researchers will assess participants' cognitive profiles, body perception, and neural responses to food-related stimuli. The study monitors these factors at baseline and aims to improve understanding of the cognitive and behavioral features that distinguish ARFID from other feeding and eating disorders. Participation involves non-invasive and safe procedures conducted under medical supervision.

CONDITIONS

Brief Title

Cognitive Evaluation of Patients With Eating Disorders

Who Can Participate

Age: 14Years - 65Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of a Feeding and Eating Disorder (ARFID, anorexia nervosa, or bulimia nervosa)
  • Patients of both sexes
  • Age between 14 and 65 years
  • Confirmed diagnosis of a Feeding and Eating Disorder
  • Body Mass Index (BMI) < 25
  • Signed informed consent form for participation in the study
Not Eligible

You will not qualify if you...

  • Diagnosis of Bipolar Disorder according to DSM-5-TR criteria
  • Diagnosis of a Schizophrenia Spectrum Disorder according to DSM-5-TR criteria
  • Intellectual disability according to DSM-5-TR criteria
  • Presence of brain tumors
  • History of seizure events
  • Presence of other moderate to severe neurological disorders
  • Lack of the patient's consent to voluntary participation in the study
  • Lack of parental or legal guardian consent for participation of a minor in the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Single session

Participants complete behavioral tasks designed to evaluate cognitive functions related to eating disorders, including inhibitory response and body image association.

1 visit (in-person)

Trial Site Locations

Total: 3 locations

1

IUSS Pavia - Istituto Universitario di Studi Superiori

Pavia, PV, Italy, 27100

Actively Recruiting

2

Istituto Psicologico Italiano s.r.l.s.

Milan, Italy, 20124

Actively Recruiting

3

ASST Fatebenefratelli Sacco

Milan, Italy, 20157

Actively Recruiting

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Research Team

G

Giulia Mattavelli, Associated prof., researcher

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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