Study of Cognitive Changes After Radiation Therapy in Adults with Various Primary Brain Tumors Excluding Glioblastoma

What this Trial Is About

Researchers are evaluating cognitive function in adults with various primary brain tumours, excluding glioblastoma, who are treated with radiation therapy RT. The study aims to understand how RT affects cognitive abilities over time and to develop parameters related to radiation sensitivity and brain volume effects that contribute to cognitive dysfunction. This prospective nationwide study includes about 300 patients from specialized centers in Denmark. Participants will undergo a series of standardized cognitive tests and complete questionnaires before starting RT and again at 1, 3, 5, and 10 years after treatment. The tests assess functions such as verbal learning and memory, attention, processing speed, and executive function. The questionnaires measure quality of life, fatigue, sleep quality, depression, anxiety, and socio-demographic factors. Researchers will examine how cognitive test results relate to radiation dose levels received by specific brain regions. Throughout the study, patients will be closely monitored with these cognitive assessments and patient-reported outcomes to track changes over time. The primary outcome is the impairment of verbal learning and memory after 10 years, evaluated by the HVLT-r test. Secondary outcomes include various cognitive functions, quality of life measures, and side effects related to radiation therapy. This long-term follow-up will help identify brain areas most affected by radiation and guide future treatment planning.

Cognitive Function After Radiation Therapy for Primary Brain Tumours