Effects of obstructive sleep apnea treatment on neurodegenerative biomarker neurofilament light chain and cognitive performance.
Tony Sehr, Katja Akgün, Pascal Benkert...
https://pubmed.ncbi.nlm.nih.gov/38351662/Actively Recruiting
Led by Comenius University · Updated on 2026-01-23
30
Participants Needed
1
Research Sites
17 weeks
Total Duration
Obstructive sleep apnea OSA is a common sleep disorder linked to cognitive decline and risks for neurodegeneration. This research examines how OSA affects cognition and related physiological processes in 100 adults newly diagnosed with OSA who have no other chronic diseases except overweight or obesity and are not on chronic medications. The study aims to better understand cognitive impairment profiles in OSA and explore connections with vascular, metabolic, and neuroinflammatory changes.
CONDITIONS
Cognitive Function in Obstructive Sleep Apnea
B
Branislav Kollar, prof. MD PhD. MPH.
S
Stela Biathova, MA
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Comenius University
Lead Sponsor
University Hospital Bratislava
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for overnight diagnostic sleep study
Duration - 1 night
Participants undergo overnight polysomnography (PSG) to confirm obstructive sleep apnea diagnosis and determine severity.
1 overnight visit (in-person)
Duration - 12 months
Participants with confirmed obstructive sleep apnea are observed over 12 months to assess cognitive function, sleep parameters, and related biological measures, including adherence to positive airway pressure therapy if prescribed.
2 visits (baseline and 12 months) including cognitive testing, neuroimaging, biomarker collection, and vascular assessments
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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https://pubmed.ncbi.nlm.nih.gov/39589660/Comenius University
Lead Sponsor
University Hospital Bratislava
Collaborating Sponsor