Effects of obstructive sleep apnea treatment on neurodegenerative biomarker neurofilament light chain and cognitive performance.
Tony Sehr, Katja Akgün, Pascal Benkert...
https://pubmed.ncbi.nlm.nih.gov/38351662Actively Recruiting
Age: 18Years - 65Years
All Genders
ID07364318
Cognitive Function and Pathophysiological Mechanisms in Adults With Obstructive Sleep Apnea: Long-term Impact of Positive Airway Pressure Therapy
Led by Comenius University · Updated on 2026-01-23
30
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
Sponsors
C
Comenius University
Lead Sponsor
U
University Hospital Bratislava
Collaborating Sponsor
AI-Summary
What this Trial Is About
Obstructive sleep apnea (OSA) is a common sleep disorder linked to cognitive decline and risks for neurodegeneration. This research examines how OSA affects cognition and related physiological processes in 100 adults newly diagnosed with OSA who have no other chronic diseases except overweight or obesity and are not on chronic medications. The study aims to better understand cognitive impairment profiles in OSA and explore connections with vascular, metabolic, and neuroinflammatory changes.
CONDITIONS
Brief Title
Cognitive Function in Obstructive Sleep Apnea
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Provide informed consent
- Age between 18 and 65 years
- Newly diagnosed with obstructive sleep apnea confirmed by overnight sleep study meeting specific criteria
- Able to complete all required tests and follow-up visits
You will not qualify if you...
- History of chronic diseases other than overweight or obesity
- Severe psychiatric conditions affecting cognitive functions
- Chronic use of medications or nicotine that may affect study results
- Neuropsychological assessment within 6 months before study start
- Prior treatment for obstructive sleep apnea (e.g., CPAP, surgery, oral appliance)
- Significant motor or sensory deficits affecting test participation
- Not a native Slovak speaker using the language daily
- Deemed unsuitable for enrollment by the study team based on clinical judgment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for overnight diagnostic sleep study
Diagnostic Evaluation
Duration - 1 night
Participants undergo overnight polysomnography (PSG) to confirm obstructive sleep apnea diagnosis and determine severity.
1 overnight visit (in-person)
Long-term Monitoring
Duration - 12 months
Participants with confirmed obstructive sleep apnea are observed over 12 months to assess cognitive function, sleep parameters, and related biological measures, including adherence to positive airway pressure therapy if prescribed.
2 visits (baseline and 12 months) including cognitive testing, neuroimaging, biomarker collection, and vascular assessments
Trial Site Locations
Total: 1 location
1
1st Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Slovakia
Bratislava, Slovakia, 813 72
Actively Recruiting
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Research Team
B
Branislav Kollar, prof. MD PhD. MPH.
S
Stela Biathova, MA
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Wagner A Silva, Bianca Almeida-Pititto, Ronaldo B Santos...
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Nader Salari, Habibolah Khazaie, Maryam Abolfathi...
https://pubmed.ncbi.nlm.nih.gov/34797460Impact of continuous positive airway pressure on cognitive functions in adult patients with obstructive sleep apnea: A systematic review and meta-analysis.
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https://pubmed.ncbi.nlm.nih.gov/39226674Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research.
Omonigho M Bubu, Andreia G Andrade, Ogie Q Umasabor-Bubu...
https://pubmed.ncbi.nlm.nih.gov/31881487Effects of Continuous Positive Airway Pressure on Neuroimaging Biomarkers and Cognition in Adult Obstructive Sleep Apnea: A Randomized Controlled Trial.
Huajun Xu, Yupu Liu, Chenyang Li...
https://pubmed.ncbi.nlm.nih.gov/39998447