CHARIOTPRO Longitudinal Study Tracking Brain Changes and Thinking Skills in Adults Over 65 Observing Alzheimers Disease Markers and Cognitive Health Over Time

What this Trial Is About

Alzheimers disease is a brain condition that leads to dementia, mostly affecting older adults. It progresses differently in each person, often starting with subtle memory and thinking changes that can be mistaken for normal aging. The disease begins many years before symptoms appear, with harmful protein build-up in the brain causing cell damage. This research focuses on understanding early changes in brain function and biology to help detect, diagnose, and eventually treat Alzheimers earlier. The CHARIOTPRO Longitudinal Study observes older adults aged over 65 to assess thinking skills and biological markers related to Alzheimers over time. Participants previously screened in an earlier study CPSS1 will be followed for at least three more years, extending up to 12 years for some. The study does not involve treatment but is observational, monitoring cognition and brain protein levels using blood tests and imaging data collected earlier. Blood samples will be taken annually, and cognitive tests will be conducted every six months to track changes. During visits, participants will provide health and lifestyle information, complete memory and thinking tests, and undergo blood draws. Questionnaires will be collected to understand daily function and cognitive changes. The main outcomes measured are changes in cognitive test scores over approximately eight and a half years. This study is sponsored by Imperial College London and aims to improve understanding of Alzheimers early stages to support future prevention and treatment strategies.

Cognitive Health in Ageing Register: Investigational and Observational Trial Studies in Dementia Research (CHARIOT): Prospective Readiness Cohort (PRO) Longitudinal Study