Observational Study on Cognitive Effects and Postoperative Delirium Following Surgery for Stomach or Esophageal Cancer

What this Trial Is About

Researchers are investigating the occurrence of Post Operative Delirium POD following surgery for stomach or esophageal cancer. This observational study aims to understand how often POD occurs and explore its connections with factors such as preoperative depression, frailty, quality of life, malnutrition, and muscle loss sarcopenia. Participants who experience POD will have the opportunity to share their experiences through interviews. Participants will undergo cognitive assessments using the 4AT Test at several points before chemotherapy if applicable, upon hospital admission for surgery, on days 1, 3, and 7 after surgery, and again 4 to 8 weeks post-surgery during follow-up. Various tools will be used to evaluate related health aspects, including questionnaires for quality of life, scales for frailty and depression, assessments for malnutrition, and CT scans to measure sarcopenia. Throughout the study, participants will be monitored from enrollment until about six months after surgery. Assessments include tracking the incidence of POD, measuring preoperative depression and frailty, evaluating quality of life changes, and checking nutritional status and muscle condition. Those who develop POD will be invited for a qualitative interview to capture their personal experiences. The study is sponsored by Karolinska Institutet and aims to deepen understanding of cognitive impacts related to cancer surgery.

Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer