Actively Recruiting
Cognitive Impact of Neoadjuvant Chemotherapy for Ovarian Cancer
Led by University of Wisconsin, Madison · Updated on 2026-05-05
18
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are evaluating cognitive function in patients recently diagnosed with advanced epithelial ovarian cancer who are undergoing neoadjuvant chemotherapy. The study aims to assess various aspects of cognition, including patient-reported outcomes and objective cognitive tests, over a period of approximately 10 months. This research helps understand how chemotherapy might affect learning, memory, processing speed, and executive function in this patient group. Participants will receive neoadjuvant chemotherapy typically including carboplatin and paclitaxel, with possible alternatives or additional maintenance treatments like bevacizumab or PARP inhibitors as part of their standard care. Assessments occur at baseline, after three cycles of chemotherapy, at the end of adjuvant therapy or treatment change, and six months post-treatment. Patient-reported outcomes are collected using surveys such as FACT-O and FACT-Cog, while cognitive function is evaluated through tests like the Rey Verbal Learning Test, Trail Making Test, and Controlled Oral Word Association Test. During the study, participants will complete cognitive and health assessments at multiple time points up to 10 months. These include the Mini Mental State Exam, Patient Health Questionnaire-2, and various cognitive tests to measure learning, memory, processing speed, and executive function. Distress levels are also monitored through routine clinical screenings. The study tracks changes over time to better understand cognitive impact and quality of life during and after chemotherapy.
CONDITIONS
Brief Title
Cognitive Impact of Neoadjuvant Chemotherapy for Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Pathological diagnosis of suspected epithelial ovarian cancer
- Planned to receive neoadjuvant chemotherapy with carboplatin and paclitaxel or suitable alternatives
- May receive bevacizumab and PARP inhibitors as maintenance treatment
- English as primary language
You will not qualify if you...
- History of diagnosed cognitive impairment, including dementia
- History of traumatic brain injury
- English is not the primary language
- Known hearing or visual impairment not corrected with devices
- Upper extremity motor impairment affecting ability to perform Trail Making Test
- Baseline Mini Mental State Exam score less than 18
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - Up to 2 months
Participants undergoing neoadjuvant chemotherapy are assessed for cognitive function and patient reported outcomes at baseline and after three cycles of chemotherapy.
2 visits (in-person) at baseline and after 3 chemotherapy cycles
Duration - Up to 4 months
Participants are assessed following completion of adjuvant chemotherapy or transition to an alternate treatment regimen for those who progress through primary treatment.
1 visit (in-person) after adjuvant therapy completion or treatment change
Duration - Up to 10 months on study
Participants are assessed for cognitive function and patient reported outcomes six months after treatment completion.
1 follow-up visit (in-person) approximately 6 months after treatment ends
Trial Site Locations
Total: 1 location
1
UW Carbone Cancer Center
Madison, Wisconsin, United States, 53792
Actively Recruiting
Research Team
S
Supportive Oncology
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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