China Registry Study on Cognitive Impairment in the Elderly: Protocol of a Prospective Cohort Study.
Yingying Zhu, Dong Pan, Lei He...
https://pubmed.ncbi.nlm.nih.gov/35002683Actively Recruiting
Age: 50Years +
All Genders
Healthy Volunteers
ID04360200
Cognitive Impairment in Ageing People: A Longitudinal Observational Prospective Study
Led by Yamei Tang · Updated on 2020-09-14
5000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Mild cognitive impairment (MCI) and neurocognitive disorders like Alzheimer's disease and vascular dementia are common among older adults, causing significant medical, social, and economic challenges, especially in China. This research aims to create a long-term observational study to better understand these conditions, focusing on early prevention, diagnosis, and treatment. The study also seeks to identify brain imaging and blood or cerebrospinal fluid markers that could help detect and monitor cognitive disorders early. Participants will be grouped into those experiencing normal aging with normal cognitive function and those with mild cognitive impairment marked by memory loss. The study will build a comprehensive database including epidemiological data, biological samples, and clinical information to track the progression from normal aging to dementia or Alzheimer’s disease. Advanced brain imaging techniques will be used to support precise diagnoses of cognitive disorders. During the study, which runs from April 2020 to December 2040, participants will undergo regular evaluations including cognitive assessments like the Montreal Cognitive Assessment (MoCA). Researchers will monitor the incidence of dementia and the rate at which individuals progress from normal cognition to mild impairment and dementia. Safety and cooperation with procedures such as blood sampling and imaging will be ensured, with ongoing data collection to support early intervention development.
CONDITIONS
Brief Title
Cognitive Impairment in Ageing People
Who Can Participate
Age: 50Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients over 50 years old
- Signed informed consent
- No diagnosis of dementia according to DSM-IV criteria
- Clinical dementia rating (CDR) score of 0.5
You will not qualify if you...
- Intellectual disability or mental retardation
- Refusal to undergo blood sampling, imaging, or other examinations
- Serious organic diseases, history of mental illness, or physical disabilities including severe aphasia
- Contraindications to MRI scanning
- Presence of serious physical or mental illness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Long-term Monitoring
Duration - April 2020 to December 2040
Participants are observed over time to monitor cognitive changes and progression toward dementia.
Trial Site Locations
Total: 1 location
1
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510120
Actively Recruiting
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Research Team
Y
Yamei Tang
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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