Study on Cognitive Impairment and Dementia in People Over 50 A Long-Term Observational Study Tracking Brain Health and Memory Changes

What this Trial Is About

Mild cognitive impairment MCI and neurocognitive disorders like Alzheimers disease and vascular dementia are common among older adults, causing significant medical, social, and economic challenges, especially in China. This research aims to create a long-term observational study to better understand these conditions, focusing on early prevention, diagnosis, and treatment. The study also seeks to identify brain imaging and blood or cerebrospinal fluid markers that could help detect and monitor cognitive disorders early. Participants will be grouped into those experiencing normal aging with normal cognitive function and those with mild cognitive impairment marked by memory loss. The study will build a comprehensive database including epidemiological data, biological samples, and clinical information to track the progression from normal aging to dementia or Alzheimers disease. Advanced brain imaging techniques will be used to support precise diagnoses of cognitive disorders. During the study, which runs from April 2020 to December 2040, participants will undergo regular evaluations including cognitive assessments like the Montreal Cognitive Assessment MoCA. Researchers will monitor the incidence of dementia and the rate at which individuals progress from normal cognition to mild impairment and dementia. Safety and cooperation with procedures such as blood sampling and imaging will be ensured, with ongoing data collection to support early intervention development.

Cognitive Impairment in Ageing People